High-resolution Nanopore methylome-maps reveal random hyper-methylation at CpG-poor regions as driver of chemoresistance in leukemias

Aberrant DNA methylation at CpG dinucleotides is a cancer hallmark that is associated with the emergence of resistance to anti cancer treatment, though molecular mechanisms and biological significance remain elusive. Genome scale methylation maps by currently used methods are based on chemical modif...

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Detalles Bibliográficos
Autores principales: Magi, Alberto, Mattei, Gianluca, Mingrino, Alessandra, Caprioli, Chiara, Ronchini, Chiara, Frigè, Gianmaria, Semeraro, Roberto, Bolognini, Davide, Rambaldi, Alessandro, Candoni, Anna, Colombo, Emanuela, Mazzarella, Luca, Pelicci, Pier Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082806/
https://www.ncbi.nlm.nih.gov/pubmed/37031307
http://dx.doi.org/10.1038/s42003-023-04756-8

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