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Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro
This study explored the promoting effect of oxidative stress-induced growth inhibitor family member 2(OSGIN2) on gastric cancer (GC) through public databases and in vitro experiments. The potential relationship between OSGIN2 expression, prognosis, functional enrichment of associated differential ge...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082810/ https://www.ncbi.nlm.nih.gov/pubmed/37031243 http://dx.doi.org/10.1038/s41598-023-32934-5 |
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author | Wang, Peipei Zhu, Ying Jia, Xinru Ying, Xiangchang Sun, Leitao Ruan, Shanming |
author_facet | Wang, Peipei Zhu, Ying Jia, Xinru Ying, Xiangchang Sun, Leitao Ruan, Shanming |
author_sort | Wang, Peipei |
collection | PubMed |
description | This study explored the promoting effect of oxidative stress-induced growth inhibitor family member 2(OSGIN2) on gastric cancer (GC) through public databases and in vitro experiments. The potential relationship between OSGIN2 expression, prognosis, functional enrichment of associated differential genes, immune infiltration, and mutational information in gastric cancer were comprehensively investigated using bioinformatics analysis. OSGIN2 was knocked down using small interfering RNA (siRNA) transfection for subsequent cell function testing. The results showed that gastric carcinoma cells and tissues contained high levels of OSGIN2, which was associated with a poor prognosis for GC patients. It was important in the cell cycle, autophagy, etc., and was related to a variety of tumor-related signal pathways. Knockdown of OSGIN2 inhibited tumor cell proliferation and contributed to cell cycle arrest. It was also correlated with tumor immune infiltrating cells (TILs), affecting antitumor immune function. Our analysis highlights that OSING2, as a new biomarker, has diagnostic and prognostic value in gastric cancer and is a potentially effective target in GC treatment. |
format | Online Article Text |
id | pubmed-10082810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100828102023-04-10 Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro Wang, Peipei Zhu, Ying Jia, Xinru Ying, Xiangchang Sun, Leitao Ruan, Shanming Sci Rep Article This study explored the promoting effect of oxidative stress-induced growth inhibitor family member 2(OSGIN2) on gastric cancer (GC) through public databases and in vitro experiments. The potential relationship between OSGIN2 expression, prognosis, functional enrichment of associated differential genes, immune infiltration, and mutational information in gastric cancer were comprehensively investigated using bioinformatics analysis. OSGIN2 was knocked down using small interfering RNA (siRNA) transfection for subsequent cell function testing. The results showed that gastric carcinoma cells and tissues contained high levels of OSGIN2, which was associated with a poor prognosis for GC patients. It was important in the cell cycle, autophagy, etc., and was related to a variety of tumor-related signal pathways. Knockdown of OSGIN2 inhibited tumor cell proliferation and contributed to cell cycle arrest. It was also correlated with tumor immune infiltrating cells (TILs), affecting antitumor immune function. Our analysis highlights that OSING2, as a new biomarker, has diagnostic and prognostic value in gastric cancer and is a potentially effective target in GC treatment. Nature Publishing Group UK 2023-04-08 /pmc/articles/PMC10082810/ /pubmed/37031243 http://dx.doi.org/10.1038/s41598-023-32934-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Wang, Peipei Zhu, Ying Jia, Xinru Ying, Xiangchang Sun, Leitao Ruan, Shanming Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro |
title | Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro |
title_full | Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro |
title_fullStr | Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro |
title_full_unstemmed | Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro |
title_short | Clinical prognostic value of OSGIN2 in gastric cancer and its proliferative effect in vitro |
title_sort | clinical prognostic value of osgin2 in gastric cancer and its proliferative effect in vitro |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082810/ https://www.ncbi.nlm.nih.gov/pubmed/37031243 http://dx.doi.org/10.1038/s41598-023-32934-5 |
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