Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions

SARS-CoV-2 receptor binding domains (RBDs) interact with both the ACE2 receptor and heparan sulfate on the surface of host cells to enhance SARS-CoV-2 infection. We show that suramin, a polysulfated synthetic drug, binds to the ACE2 receptor and heparan sulfate binding sites on the RBDs of wild-type...

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Detalles Bibliográficos
Autores principales: Kwon, Paul S., Xu, Shirley, Oh, Hanseul, Kwon, Seok-Joon, Rodrigues, Andre L., Feroz, Maisha, Fraser, Keith, He, Peng, Zhang, Fuming, Hong, Jung Joo, Linhardt, Robert J., Dordick, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082822/
https://www.ncbi.nlm.nih.gov/pubmed/37031303
http://dx.doi.org/10.1038/s42003-023-04789-z

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