A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation

Inhibition of amyloid-β peptide (Aβ) accumulation in the brain is a promising approach for treatment of Alzheimer’s disease (AD). Aβ is produced by β-secretase and γ-secretase in endosomes via sequential proteolysis of amyloid precursor protein (APP). Aβ and APP have a common feature to readily clus...

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Detalles Bibliográficos
Autores principales: Sato, Waka, Watanabe-Takahashi, Miho, Murata, Takuya, Utsunomiya-Tate, Naoko, Motoyama, Jun, Anzai, Masataka, Ishihara, Seiko, Nishioka, Nanako, Uchiyama, Hina, Togashi, Juri, Nishihara, Saeka, Kawasaki, Kiyoshi, Saito, Takashi, Saido, Takaomi C., Funamoto, Satoru, Nishikawa, Kiyotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082830/
https://www.ncbi.nlm.nih.gov/pubmed/37031306
http://dx.doi.org/10.1038/s42003-023-04771-9

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