A nonstop thrill ride from genes to the assembly of the T3SS injectisome

The type three secretion system (T3SS) is a membrane-anchored nano-machine utilized by many pathogenic bacteria to inject effector proteins and thus take control of host cells. In a recent article, Kaval et al. reveal a striking colocalization of a T3SS-encoding locus, its transcriptional activators...

Descripción completa

Detalles Bibliográficos
Autores principales: Fishov, Itzhak, Namboodiri, Sharanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082841/
https://www.ncbi.nlm.nih.gov/pubmed/37031218
http://dx.doi.org/10.1038/s41467-023-37753-w
Descripción
Sumario:The type three secretion system (T3SS) is a membrane-anchored nano-machine utilized by many pathogenic bacteria to inject effector proteins and thus take control of host cells. In a recent article, Kaval et al. reveal a striking colocalization of a T3SS-encoding locus, its transcriptional activators, protein products, and the complete structure at the cell membrane, which they claim provides evidence for a mechanism known as ‘transertion’.

Ejemplares similares