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Association of cognitive impairment and quality of life in patients with multiple sclerosis: A cross-sectional study

Background: Cognitive impairments in patients with multiple sclerosis (MS) are suggested as a prognostic factor for disease development, and consequently higher disability and more deficits in daily and social activities. In this regard, we aimed to investigate the association between quality of lif...

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Autores principales: Nabizadeh, Fardin, Balabandian, Mohammad, Rostami, Mohammad Reza, Owji, Mahsa, Sahraian, Mohammad Ali, Bidadian, Maryam, Ghadiri, Fereshteh, Rezaeimanesh, Nasim, Moghadasi, Abdorreza Naser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082961/
https://www.ncbi.nlm.nih.gov/pubmed/38011341
http://dx.doi.org/10.18502/cjn.v21i3.11106
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author Nabizadeh, Fardin
Balabandian, Mohammad
Rostami, Mohammad Reza
Owji, Mahsa
Sahraian, Mohammad Ali
Bidadian, Maryam
Ghadiri, Fereshteh
Rezaeimanesh, Nasim
Moghadasi, Abdorreza Naser
author_facet Nabizadeh, Fardin
Balabandian, Mohammad
Rostami, Mohammad Reza
Owji, Mahsa
Sahraian, Mohammad Ali
Bidadian, Maryam
Ghadiri, Fereshteh
Rezaeimanesh, Nasim
Moghadasi, Abdorreza Naser
author_sort Nabizadeh, Fardin
collection PubMed
description Background: Cognitive impairments in patients with multiple sclerosis (MS) are suggested as a prognostic factor for disease development, and consequently higher disability and more deficits in daily and social activities. In this regard, we aimed to investigate the association between quality of life (QOL) and cognitive function in patients with MS. Methods: We conducted a cross-sectional study on patients with relapsing-remitting MS (RRMS). General characteristic variables were carried out, and then all patients underwent assessments such as Multiple Sclerosis Quality of Life-54 (MSQOL-54), Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS), Expanded Disability Status Scale (EDSS), Beck Depression Inventory-II (BDI-II), and North American Adult Reading Test (NAART). Results: In the present study, a total of 92 patients, including 76 women with a mean disease duration of 6.82 ± 4.80 years were involved. Results of simple Pearson correlation revealed a significant positive relation between California Verbal Learning Test (CVLT) total learning with MSQOL mental health (r = 0.267, P = 0.017) and physical health (r = 0.299, P = 0.007). After adjusting for potential confounders, there was a negative correlation between MSQOL mental health with Delis-Kaplan Executive Function System (D-KEFS) (r = -0.303, P = 0.015) and Judgment of Line Orientation (JLO) (r = -0.310, P = 0.013). Besides, MSQOL physical health was negatively associated with Brief Visuospatial Memory Test-Revised (BVMT-R) in the adjusted model (r = -0.270, P = 0.031). Conclusion: There is a statistically significant association between specific aspects of cognitive decline and QOL. Therefore, more attention should be paid to cognitive impairment in patients with MS as based on our findings, it is significantly associated with QOL.
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spelling pubmed-100829612023-04-10 Association of cognitive impairment and quality of life in patients with multiple sclerosis: A cross-sectional study Nabizadeh, Fardin Balabandian, Mohammad Rostami, Mohammad Reza Owji, Mahsa Sahraian, Mohammad Ali Bidadian, Maryam Ghadiri, Fereshteh Rezaeimanesh, Nasim Moghadasi, Abdorreza Naser Curr J Neurol Original Article Background: Cognitive impairments in patients with multiple sclerosis (MS) are suggested as a prognostic factor for disease development, and consequently higher disability and more deficits in daily and social activities. In this regard, we aimed to investigate the association between quality of life (QOL) and cognitive function in patients with MS. Methods: We conducted a cross-sectional study on patients with relapsing-remitting MS (RRMS). General characteristic variables were carried out, and then all patients underwent assessments such as Multiple Sclerosis Quality of Life-54 (MSQOL-54), Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS), Expanded Disability Status Scale (EDSS), Beck Depression Inventory-II (BDI-II), and North American Adult Reading Test (NAART). Results: In the present study, a total of 92 patients, including 76 women with a mean disease duration of 6.82 ± 4.80 years were involved. Results of simple Pearson correlation revealed a significant positive relation between California Verbal Learning Test (CVLT) total learning with MSQOL mental health (r = 0.267, P = 0.017) and physical health (r = 0.299, P = 0.007). After adjusting for potential confounders, there was a negative correlation between MSQOL mental health with Delis-Kaplan Executive Function System (D-KEFS) (r = -0.303, P = 0.015) and Judgment of Line Orientation (JLO) (r = -0.310, P = 0.013). Besides, MSQOL physical health was negatively associated with Brief Visuospatial Memory Test-Revised (BVMT-R) in the adjusted model (r = -0.270, P = 0.031). Conclusion: There is a statistically significant association between specific aspects of cognitive decline and QOL. Therefore, more attention should be paid to cognitive impairment in patients with MS as based on our findings, it is significantly associated with QOL. Tehran University of Medical Sciences 2022-07-06 /pmc/articles/PMC10082961/ /pubmed/38011341 http://dx.doi.org/10.18502/cjn.v21i3.11106 Text en Copyright © 2022 Iranian Neurological Association, and Tehran University of Medical Sciences Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Nabizadeh, Fardin
Balabandian, Mohammad
Rostami, Mohammad Reza
Owji, Mahsa
Sahraian, Mohammad Ali
Bidadian, Maryam
Ghadiri, Fereshteh
Rezaeimanesh, Nasim
Moghadasi, Abdorreza Naser
Association of cognitive impairment and quality of life in patients with multiple sclerosis: A cross-sectional study
title Association of cognitive impairment and quality of life in patients with multiple sclerosis: A cross-sectional study
title_full Association of cognitive impairment and quality of life in patients with multiple sclerosis: A cross-sectional study
title_fullStr Association of cognitive impairment and quality of life in patients with multiple sclerosis: A cross-sectional study
title_full_unstemmed Association of cognitive impairment and quality of life in patients with multiple sclerosis: A cross-sectional study
title_short Association of cognitive impairment and quality of life in patients with multiple sclerosis: A cross-sectional study
title_sort association of cognitive impairment and quality of life in patients with multiple sclerosis: a cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082961/
https://www.ncbi.nlm.nih.gov/pubmed/38011341
http://dx.doi.org/10.18502/cjn.v21i3.11106
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