Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses

Treatment of severe cases of coronavirus disease 2019 (COVID-19) is extremely important to minimize death and end-organ damage. Here we performed a proteomic analysis of plasma samples from mild, moderate and severe COVID-19 patients. Analysis revealed differentially expressed proteins and different...

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Autores principales: Alghanem, Bandar, Mansour, Fatmah A., Shaibah, Hayat, Almuhalhil, Khawlah, Almourfi, Feras, Alamri, Hassan S., Alajmi, Hala, Rashid, Mamoon, Alroqi, Fayhan, Jalouli, Maroua, Harrath, Abdel Halim, Boudjellal, Mohammad, Barhoumi, Tlili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082967/
https://www.ncbi.nlm.nih.gov/pubmed/37064481
http://dx.doi.org/10.1016/j.heliyon.2023.e15224
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author Alghanem, Bandar
Mansour, Fatmah A.
Shaibah, Hayat
Almuhalhil, Khawlah
Almourfi, Feras
Alamri, Hassan S.
Alajmi, Hala
Rashid, Mamoon
Alroqi, Fayhan
Jalouli, Maroua
Harrath, Abdel Halim
Boudjellal, Mohammad
Barhoumi, Tlili
author_facet Alghanem, Bandar
Mansour, Fatmah A.
Shaibah, Hayat
Almuhalhil, Khawlah
Almourfi, Feras
Alamri, Hassan S.
Alajmi, Hala
Rashid, Mamoon
Alroqi, Fayhan
Jalouli, Maroua
Harrath, Abdel Halim
Boudjellal, Mohammad
Barhoumi, Tlili
author_sort Alghanem, Bandar
collection PubMed
description Treatment of severe cases of coronavirus disease 2019 (COVID-19) is extremely important to minimize death and end-organ damage. Here we performed a proteomic analysis of plasma samples from mild, moderate and severe COVID-19 patients. Analysis revealed differentially expressed proteins and different therapeutic potential targets related to innate immune responses such as fetuin-A, tetranectin (TN) and paraoxonase-1 (PON1). Furthermore, protein changes in plasma showed dysregulation of complement and coagulation cascades in COVID-19 patients compared to healthy controls. In conclusion, our proteomics data suggested fetuin-A and TN as potential targets that might be used for diagnosis as well as signatures for a better understanding of the pathogenesis of COVID-19 disease.
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spelling pubmed-100829672023-04-10 Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses Alghanem, Bandar Mansour, Fatmah A. Shaibah, Hayat Almuhalhil, Khawlah Almourfi, Feras Alamri, Hassan S. Alajmi, Hala Rashid, Mamoon Alroqi, Fayhan Jalouli, Maroua Harrath, Abdel Halim Boudjellal, Mohammad Barhoumi, Tlili Heliyon Research Article Treatment of severe cases of coronavirus disease 2019 (COVID-19) is extremely important to minimize death and end-organ damage. Here we performed a proteomic analysis of plasma samples from mild, moderate and severe COVID-19 patients. Analysis revealed differentially expressed proteins and different therapeutic potential targets related to innate immune responses such as fetuin-A, tetranectin (TN) and paraoxonase-1 (PON1). Furthermore, protein changes in plasma showed dysregulation of complement and coagulation cascades in COVID-19 patients compared to healthy controls. In conclusion, our proteomics data suggested fetuin-A and TN as potential targets that might be used for diagnosis as well as signatures for a better understanding of the pathogenesis of COVID-19 disease. Elsevier 2023-04-09 /pmc/articles/PMC10082967/ /pubmed/37064481 http://dx.doi.org/10.1016/j.heliyon.2023.e15224 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Alghanem, Bandar
Mansour, Fatmah A.
Shaibah, Hayat
Almuhalhil, Khawlah
Almourfi, Feras
Alamri, Hassan S.
Alajmi, Hala
Rashid, Mamoon
Alroqi, Fayhan
Jalouli, Maroua
Harrath, Abdel Halim
Boudjellal, Mohammad
Barhoumi, Tlili
Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses
title Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses
title_full Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses
title_fullStr Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses
title_full_unstemmed Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses
title_short Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses
title_sort quantitative proteomics analysis of covid-19 patients: fetuin-a and tetranectin as potential modulators of innate immune responses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10082967/
https://www.ncbi.nlm.nih.gov/pubmed/37064481
http://dx.doi.org/10.1016/j.heliyon.2023.e15224
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