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Impact of Cataract Surgery on IOP and Ocular Structures in Normotensive Patients and Primary and Exfoliation Open-Angle Glaucoma Patients

PURPOSE: The aim of this study was to evaluate and compare the changes in Intraocular Pressure (IOP) and other ocular parameters: the Anterior Chamber Angle (ACA), Anterior Chamber Volume (ACV), and Anterior Chamber Depth (ACD) during phacoemulsification surgery in Greek patients with normotensive e...

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Autores principales: Xirou, Vasiliki, Xirou, Tina, Siganos, Charalambos, Ntonti, Panagiota, Georgakopoulos, Constantinos, Stavrakas, Panagiotis, Makri, Olga E, Kanakis, Menelaos, Tsapardoni, Foteini, Fragkoulis, Ioannis, Garnavou-Xirou, Christina, Kozobolis, Vassilios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083030/
https://www.ncbi.nlm.nih.gov/pubmed/37041963
http://dx.doi.org/10.2147/OPTH.S402550
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author Xirou, Vasiliki
Xirou, Tina
Siganos, Charalambos
Ntonti, Panagiota
Georgakopoulos, Constantinos
Stavrakas, Panagiotis
Makri, Olga E
Kanakis, Menelaos
Tsapardoni, Foteini
Fragkoulis, Ioannis
Garnavou-Xirou, Christina
Kozobolis, Vassilios
author_facet Xirou, Vasiliki
Xirou, Tina
Siganos, Charalambos
Ntonti, Panagiota
Georgakopoulos, Constantinos
Stavrakas, Panagiotis
Makri, Olga E
Kanakis, Menelaos
Tsapardoni, Foteini
Fragkoulis, Ioannis
Garnavou-Xirou, Christina
Kozobolis, Vassilios
author_sort Xirou, Vasiliki
collection PubMed
description PURPOSE: The aim of this study was to evaluate and compare the changes in Intraocular Pressure (IOP) and other ocular parameters: the Anterior Chamber Angle (ACA), Anterior Chamber Volume (ACV), and Anterior Chamber Depth (ACD) during phacoemulsification surgery in Greek patients with normotensive eyes and those with well-controlled Open-Angle Glaucoma (OAG). Additionally, parameters such as the Corneal Thickness (CCT), Axial Length (AL), Central Macular Thickness (CMT), and Retinal Nerve Fibre Layer (RNFL) were also examined. PATIENTS AND METHODS: This was a prospective observational case–control study that included 50 phakic eyes, 25 normotensive (Group 1), and 25 with OAG: 15 Primary Open-Angle Glaucoma (POAG) and 10 Exfoliation Glaucoma (EXG) (Group 2). Ophthalmic assessment included IOP measurements, ocular biometry, and anterior and posterior segment optical coherence tomography evaluation of the aforementioned ocular parameters, prior and 6 months after phacoemulsification surgery. RESULTS: At the 6 months post-operative review, a greater IOP reduction was recorded in eyes with OAG, in comparison to normotensive ones (5.3mmHg and 1.6 mmHg respectively). In addition, a significant but similar increase was recorded in the values of the ACA, ACV, and ACD of both groups between the pre- and the post-op period. Furthermore, the CCT and AL values remained unaltered. Finally, there was a non-statistically significant change in the mean CMT and the mean average RNFL of both groups. CONCLUSION: Eyes with OAG tend to undergo a greater reduction in IOP post-phacoemulsification surgery, in comparison to normotensive eyes. This reduction may not be solely attributed to ocular anatomical changes after phacoemulsification surgery but may also be due to the remodeling of the trabecular meshwork and the ciliary body. This may be especially true in the case of OAG eyes, which already start off with a compromised trabecular endothelium prior to surgery.
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spelling pubmed-100830302023-04-10 Impact of Cataract Surgery on IOP and Ocular Structures in Normotensive Patients and Primary and Exfoliation Open-Angle Glaucoma Patients Xirou, Vasiliki Xirou, Tina Siganos, Charalambos Ntonti, Panagiota Georgakopoulos, Constantinos Stavrakas, Panagiotis Makri, Olga E Kanakis, Menelaos Tsapardoni, Foteini Fragkoulis, Ioannis Garnavou-Xirou, Christina Kozobolis, Vassilios Clin Ophthalmol Original Research PURPOSE: The aim of this study was to evaluate and compare the changes in Intraocular Pressure (IOP) and other ocular parameters: the Anterior Chamber Angle (ACA), Anterior Chamber Volume (ACV), and Anterior Chamber Depth (ACD) during phacoemulsification surgery in Greek patients with normotensive eyes and those with well-controlled Open-Angle Glaucoma (OAG). Additionally, parameters such as the Corneal Thickness (CCT), Axial Length (AL), Central Macular Thickness (CMT), and Retinal Nerve Fibre Layer (RNFL) were also examined. PATIENTS AND METHODS: This was a prospective observational case–control study that included 50 phakic eyes, 25 normotensive (Group 1), and 25 with OAG: 15 Primary Open-Angle Glaucoma (POAG) and 10 Exfoliation Glaucoma (EXG) (Group 2). Ophthalmic assessment included IOP measurements, ocular biometry, and anterior and posterior segment optical coherence tomography evaluation of the aforementioned ocular parameters, prior and 6 months after phacoemulsification surgery. RESULTS: At the 6 months post-operative review, a greater IOP reduction was recorded in eyes with OAG, in comparison to normotensive ones (5.3mmHg and 1.6 mmHg respectively). In addition, a significant but similar increase was recorded in the values of the ACA, ACV, and ACD of both groups between the pre- and the post-op period. Furthermore, the CCT and AL values remained unaltered. Finally, there was a non-statistically significant change in the mean CMT and the mean average RNFL of both groups. CONCLUSION: Eyes with OAG tend to undergo a greater reduction in IOP post-phacoemulsification surgery, in comparison to normotensive eyes. This reduction may not be solely attributed to ocular anatomical changes after phacoemulsification surgery but may also be due to the remodeling of the trabecular meshwork and the ciliary body. This may be especially true in the case of OAG eyes, which already start off with a compromised trabecular endothelium prior to surgery. Dove 2023-04-05 /pmc/articles/PMC10083030/ /pubmed/37041963 http://dx.doi.org/10.2147/OPTH.S402550 Text en © 2023 Xirou et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Xirou, Vasiliki
Xirou, Tina
Siganos, Charalambos
Ntonti, Panagiota
Georgakopoulos, Constantinos
Stavrakas, Panagiotis
Makri, Olga E
Kanakis, Menelaos
Tsapardoni, Foteini
Fragkoulis, Ioannis
Garnavou-Xirou, Christina
Kozobolis, Vassilios
Impact of Cataract Surgery on IOP and Ocular Structures in Normotensive Patients and Primary and Exfoliation Open-Angle Glaucoma Patients
title Impact of Cataract Surgery on IOP and Ocular Structures in Normotensive Patients and Primary and Exfoliation Open-Angle Glaucoma Patients
title_full Impact of Cataract Surgery on IOP and Ocular Structures in Normotensive Patients and Primary and Exfoliation Open-Angle Glaucoma Patients
title_fullStr Impact of Cataract Surgery on IOP and Ocular Structures in Normotensive Patients and Primary and Exfoliation Open-Angle Glaucoma Patients
title_full_unstemmed Impact of Cataract Surgery on IOP and Ocular Structures in Normotensive Patients and Primary and Exfoliation Open-Angle Glaucoma Patients
title_short Impact of Cataract Surgery on IOP and Ocular Structures in Normotensive Patients and Primary and Exfoliation Open-Angle Glaucoma Patients
title_sort impact of cataract surgery on iop and ocular structures in normotensive patients and primary and exfoliation open-angle glaucoma patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083030/
https://www.ncbi.nlm.nih.gov/pubmed/37041963
http://dx.doi.org/10.2147/OPTH.S402550
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