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Solid-Phase Polymerization Using Anion-Exchange Resin Can Almost Completely Crosslink Hemoglobin to Prepare Hemoglobin-Based Oxygen Carriers

INTRODUCTION: A limitation of hemoglobin-based oxygen carriers (HBOCs) as oxygen therapeutics is unpolymerized hemoglobin, which induces vasoconstriction leading to hypertension. The removal of unpolymerized hemoglobin from polymerized hemoglobin (PolyHb) is complex, expensive, and time-consuming. M...

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Detalles Bibliográficos
Autores principales:	Hui, Wenli, Mu, Wenhua, Zhao, Cong, Xue, Dan, Zhong, Zihua, Fang, Yani, Gao, Ming, Li, Xiao, Gao, Shihao, Liu, Kaiyue, Yan, Kunping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083038/ https://www.ncbi.nlm.nih.gov/pubmed/37041816 http://dx.doi.org/10.2147/IJN.S403739

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