A cationic motif upstream Engrailed2 homeodomain controls cell internalization through selective interaction with heparan sulfates

Engrailed2 (En2) is a transcription factor that transfers from cell to cell through unconventional pathways. The poorly understood internalization mechanism of this cationic protein is proposed to require an initial interaction with cell-surface glycosaminoglycans (GAGs). To decipher the role of GAG...

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Detalles Bibliográficos
Autores principales: Cardon, Sébastien, Hervis, Yadira P., Bolbach, Gérard, Lopin-Bon, Chrystel, Jacquinet, Jean-Claude, Illien, Françoise, Walrant, Astrid, Ravault, Delphine, He, Bingwei, Molina, Laura, Burlina, Fabienne, Lequin, Olivier, Joliot, Alain, Carlier, Ludovic, Sagan, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083169/
https://www.ncbi.nlm.nih.gov/pubmed/37032404
http://dx.doi.org/10.1038/s41467-023-37757-6

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