Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome

Large serine recombinases (LSRs) are DNA integrases that facilitate the site-specific integration of mobile genetic elements into bacterial genomes. Only a few LSRs, such as Bxb1 and PhiC31, have been characterized to date, with limited efficiency as tools for DNA integration in human cells. In this...

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Detalles Bibliográficos
Autores principales: Durrant, Matthew G., Fanton, Alison, Tycko, Josh, Hinks, Michaela, Chandrasekaran, Sita S., Perry, Nicholas T., Schaepe, Julia, Du, Peter P., Lotfy, Peter, Bassik, Michael C., Bintu, Lacramioara, Bhatt, Ami S., Hsu, Patrick D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083194/
https://www.ncbi.nlm.nih.gov/pubmed/36217031
http://dx.doi.org/10.1038/s41587-022-01494-w

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