Nanofat lysate ameliorates pain and cartilage degradation of osteoarthritis through activation of TGF-β–Smad2/3 signaling of chondrocytes

Introduction: Nanofat is an effective cell therapy for osteoarthritis (OA). However, it has clinical limitations due to its short half-life. We developed Nanofat lysate (NFL) to overcome the defect of Nanofat and explore its anti-OA efficacy and mechanism. Methods: Monoiodoacetate (MIA) was employed...

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Detalles Bibliográficos
Autores principales: Ge, Yanzhi, Xu, Wenting, Chen, Zuxiang, Zhang, Haiyan, Zhang, Wenbo, Chen, Junjie, Huang, Jiefeng, Du, Wenxi, Tong, Peijian, Shan, Letian, Zhou, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083246/
https://www.ncbi.nlm.nih.gov/pubmed/37050907
http://dx.doi.org/10.3389/fphar.2023.900205

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