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Progress in 7SK ribonucleoprotein structural biology

The 7SK ribonucleoprotein (RNP) is a dynamic and multifunctional regulator of RNA Polymerase II (RNAPII) transcription in metazoa. Comprised of the non-coding 7SK RNA, core proteins, and numerous accessory proteins, the most well-known 7SK RNP function is the sequestration and inactivation of the po...

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Autores principales: Camara, Momodou B., Sobeh, Amr M., Eichhorn, Catherine D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083321/
https://www.ncbi.nlm.nih.gov/pubmed/37051324
http://dx.doi.org/10.3389/fmolb.2023.1154622
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author Camara, Momodou B.
Sobeh, Amr M.
Eichhorn, Catherine D.
author_facet Camara, Momodou B.
Sobeh, Amr M.
Eichhorn, Catherine D.
author_sort Camara, Momodou B.
collection PubMed
description The 7SK ribonucleoprotein (RNP) is a dynamic and multifunctional regulator of RNA Polymerase II (RNAPII) transcription in metazoa. Comprised of the non-coding 7SK RNA, core proteins, and numerous accessory proteins, the most well-known 7SK RNP function is the sequestration and inactivation of the positive transcription elongation factor b (P-TEFb). More recently, 7SK RNP has been shown to regulate RNAPII transcription through P-TEFb-independent pathways. Due to its fundamental role in cellular function, dysregulation has been linked with human diseases including cancers, heart disease, developmental disorders, and viral infection. Significant advances in 7SK RNP structural biology have improved our understanding of 7SK RNP assembly and function. Here, we review progress in understanding the structural basis of 7SK RNA folding, biogenesis, and RNP assembly.
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spelling pubmed-100833212023-04-11 Progress in 7SK ribonucleoprotein structural biology Camara, Momodou B. Sobeh, Amr M. Eichhorn, Catherine D. Front Mol Biosci Molecular Biosciences The 7SK ribonucleoprotein (RNP) is a dynamic and multifunctional regulator of RNA Polymerase II (RNAPII) transcription in metazoa. Comprised of the non-coding 7SK RNA, core proteins, and numerous accessory proteins, the most well-known 7SK RNP function is the sequestration and inactivation of the positive transcription elongation factor b (P-TEFb). More recently, 7SK RNP has been shown to regulate RNAPII transcription through P-TEFb-independent pathways. Due to its fundamental role in cellular function, dysregulation has been linked with human diseases including cancers, heart disease, developmental disorders, and viral infection. Significant advances in 7SK RNP structural biology have improved our understanding of 7SK RNP assembly and function. Here, we review progress in understanding the structural basis of 7SK RNA folding, biogenesis, and RNP assembly. Frontiers Media S.A. 2023-03-27 /pmc/articles/PMC10083321/ /pubmed/37051324 http://dx.doi.org/10.3389/fmolb.2023.1154622 Text en Copyright © 2023 Camara, Sobeh and Eichhorn. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Camara, Momodou B.
Sobeh, Amr M.
Eichhorn, Catherine D.
Progress in 7SK ribonucleoprotein structural biology
title Progress in 7SK ribonucleoprotein structural biology
title_full Progress in 7SK ribonucleoprotein structural biology
title_fullStr Progress in 7SK ribonucleoprotein structural biology
title_full_unstemmed Progress in 7SK ribonucleoprotein structural biology
title_short Progress in 7SK ribonucleoprotein structural biology
title_sort progress in 7sk ribonucleoprotein structural biology
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083321/
https://www.ncbi.nlm.nih.gov/pubmed/37051324
http://dx.doi.org/10.3389/fmolb.2023.1154622
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