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Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study
PURPOSE: Liver grafts from donors with HBV infection contributed to expanding the donor pool under the hepatitis B immunoglobulin and antiviral agents (nucleos(t)ide analogues) in the HBV-endemic area. We report long-term outcomes of liver transplantations (LTs) using grafts from donors with active...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Surgical Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083344/ https://www.ncbi.nlm.nih.gov/pubmed/37051154 http://dx.doi.org/10.4174/astr.2023.104.4.183 |
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author | Gang, Sujin Choi, YoungRok Lee, Boram Yoon, Kyung Chul Hong, Su young Suh, Sanggyun Han, Eui Soo Hong, Suk Kyun Lee, Hae Won Cho, Jai Young Yi, Nam-joon Lee, Kwang-Woong Suh, Kyung-Suk |
author_facet | Gang, Sujin Choi, YoungRok Lee, Boram Yoon, Kyung Chul Hong, Su young Suh, Sanggyun Han, Eui Soo Hong, Suk Kyun Lee, Hae Won Cho, Jai Young Yi, Nam-joon Lee, Kwang-Woong Suh, Kyung-Suk |
author_sort | Gang, Sujin |
collection | PubMed |
description | PURPOSE: Liver grafts from donors with HBV infection contributed to expanding the donor pool under the hepatitis B immunoglobulin and antiviral agents (nucleos(t)ide analogues) in the HBV-endemic area. We report long-term outcomes of liver transplantations (LTs) using grafts from donors with active or chronic HBV infection. METHODS: Overall, 2,260 LTs performed in 3 major hospitals in Seoul from January 2000 to April 2019 were assessed for inclusion. Twenty-six grafts (1.2%) were obtained from HBsAg (+), HBeAb (+), or HBcAb (+) donors, and recipient outcomes were retrospectively reviewed. Donor and recipient demographics and transplantation outcomes were analyzed. RESULTS: Sixteen deceased donor LTs were performed using active HBsAg (+) grafts. Ten other LTs were sourced from 10 living donors. There was no significant difference in survival in patients who received deceased donor LTs compared with that in those who underwent LT with non–hepatitis virus-infected grafts. Fourteen patients who were followed up for >5 years were stable, and no difference in hepatocellular carcinoma recurrence rate was observed 5 years after transplantation between transplants from donors with and those without HBV. CONCLUSION: Considering long-term outcomes, liver grafts from donors with active HBV replication can be safely used for LT. |
format | Online Article Text |
id | pubmed-10083344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Surgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-100833442023-04-11 Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study Gang, Sujin Choi, YoungRok Lee, Boram Yoon, Kyung Chul Hong, Su young Suh, Sanggyun Han, Eui Soo Hong, Suk Kyun Lee, Hae Won Cho, Jai Young Yi, Nam-joon Lee, Kwang-Woong Suh, Kyung-Suk Ann Surg Treat Res Original Article PURPOSE: Liver grafts from donors with HBV infection contributed to expanding the donor pool under the hepatitis B immunoglobulin and antiviral agents (nucleos(t)ide analogues) in the HBV-endemic area. We report long-term outcomes of liver transplantations (LTs) using grafts from donors with active or chronic HBV infection. METHODS: Overall, 2,260 LTs performed in 3 major hospitals in Seoul from January 2000 to April 2019 were assessed for inclusion. Twenty-six grafts (1.2%) were obtained from HBsAg (+), HBeAb (+), or HBcAb (+) donors, and recipient outcomes were retrospectively reviewed. Donor and recipient demographics and transplantation outcomes were analyzed. RESULTS: Sixteen deceased donor LTs were performed using active HBsAg (+) grafts. Ten other LTs were sourced from 10 living donors. There was no significant difference in survival in patients who received deceased donor LTs compared with that in those who underwent LT with non–hepatitis virus-infected grafts. Fourteen patients who were followed up for >5 years were stable, and no difference in hepatocellular carcinoma recurrence rate was observed 5 years after transplantation between transplants from donors with and those without HBV. CONCLUSION: Considering long-term outcomes, liver grafts from donors with active HBV replication can be safely used for LT. The Korean Surgical Society 2023-04 2023-03-31 /pmc/articles/PMC10083344/ /pubmed/37051154 http://dx.doi.org/10.4174/astr.2023.104.4.183 Text en Copyright © 2023, the Korean Surgical Society https://creativecommons.org/licenses/by-nc/4.0/Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Gang, Sujin Choi, YoungRok Lee, Boram Yoon, Kyung Chul Hong, Su young Suh, Sanggyun Han, Eui Soo Hong, Suk Kyun Lee, Hae Won Cho, Jai Young Yi, Nam-joon Lee, Kwang-Woong Suh, Kyung-Suk Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study |
title | Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study |
title_full | Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study |
title_fullStr | Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study |
title_full_unstemmed | Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study |
title_short | Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study |
title_sort | long-term outcomes of liver transplantation using grafts from donors with active hepatitis b virus replication: a multicenter cohort study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083344/ https://www.ncbi.nlm.nih.gov/pubmed/37051154 http://dx.doi.org/10.4174/astr.2023.104.4.183 |
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