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Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study

PURPOSE: Liver grafts from donors with HBV infection contributed to expanding the donor pool under the hepatitis B immunoglobulin and antiviral agents (nucleos(t)ide analogues) in the HBV-endemic area. We report long-term outcomes of liver transplantations (LTs) using grafts from donors with active...

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Autores principales: Gang, Sujin, Choi, YoungRok, Lee, Boram, Yoon, Kyung Chul, Hong, Su young, Suh, Sanggyun, Han, Eui Soo, Hong, Suk Kyun, Lee, Hae Won, Cho, Jai Young, Yi, Nam-joon, Lee, Kwang-Woong, Suh, Kyung-Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083344/
https://www.ncbi.nlm.nih.gov/pubmed/37051154
http://dx.doi.org/10.4174/astr.2023.104.4.183
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author Gang, Sujin
Choi, YoungRok
Lee, Boram
Yoon, Kyung Chul
Hong, Su young
Suh, Sanggyun
Han, Eui Soo
Hong, Suk Kyun
Lee, Hae Won
Cho, Jai Young
Yi, Nam-joon
Lee, Kwang-Woong
Suh, Kyung-Suk
author_facet Gang, Sujin
Choi, YoungRok
Lee, Boram
Yoon, Kyung Chul
Hong, Su young
Suh, Sanggyun
Han, Eui Soo
Hong, Suk Kyun
Lee, Hae Won
Cho, Jai Young
Yi, Nam-joon
Lee, Kwang-Woong
Suh, Kyung-Suk
author_sort Gang, Sujin
collection PubMed
description PURPOSE: Liver grafts from donors with HBV infection contributed to expanding the donor pool under the hepatitis B immunoglobulin and antiviral agents (nucleos(t)ide analogues) in the HBV-endemic area. We report long-term outcomes of liver transplantations (LTs) using grafts from donors with active or chronic HBV infection. METHODS: Overall, 2,260 LTs performed in 3 major hospitals in Seoul from January 2000 to April 2019 were assessed for inclusion. Twenty-six grafts (1.2%) were obtained from HBsAg (+), HBeAb (+), or HBcAb (+) donors, and recipient outcomes were retrospectively reviewed. Donor and recipient demographics and transplantation outcomes were analyzed. RESULTS: Sixteen deceased donor LTs were performed using active HBsAg (+) grafts. Ten other LTs were sourced from 10 living donors. There was no significant difference in survival in patients who received deceased donor LTs compared with that in those who underwent LT with non–hepatitis virus-infected grafts. Fourteen patients who were followed up for >5 years were stable, and no difference in hepatocellular carcinoma recurrence rate was observed 5 years after transplantation between transplants from donors with and those without HBV. CONCLUSION: Considering long-term outcomes, liver grafts from donors with active HBV replication can be safely used for LT.
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spelling pubmed-100833442023-04-11 Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study Gang, Sujin Choi, YoungRok Lee, Boram Yoon, Kyung Chul Hong, Su young Suh, Sanggyun Han, Eui Soo Hong, Suk Kyun Lee, Hae Won Cho, Jai Young Yi, Nam-joon Lee, Kwang-Woong Suh, Kyung-Suk Ann Surg Treat Res Original Article PURPOSE: Liver grafts from donors with HBV infection contributed to expanding the donor pool under the hepatitis B immunoglobulin and antiviral agents (nucleos(t)ide analogues) in the HBV-endemic area. We report long-term outcomes of liver transplantations (LTs) using grafts from donors with active or chronic HBV infection. METHODS: Overall, 2,260 LTs performed in 3 major hospitals in Seoul from January 2000 to April 2019 were assessed for inclusion. Twenty-six grafts (1.2%) were obtained from HBsAg (+), HBeAb (+), or HBcAb (+) donors, and recipient outcomes were retrospectively reviewed. Donor and recipient demographics and transplantation outcomes were analyzed. RESULTS: Sixteen deceased donor LTs were performed using active HBsAg (+) grafts. Ten other LTs were sourced from 10 living donors. There was no significant difference in survival in patients who received deceased donor LTs compared with that in those who underwent LT with non–hepatitis virus-infected grafts. Fourteen patients who were followed up for >5 years were stable, and no difference in hepatocellular carcinoma recurrence rate was observed 5 years after transplantation between transplants from donors with and those without HBV. CONCLUSION: Considering long-term outcomes, liver grafts from donors with active HBV replication can be safely used for LT. The Korean Surgical Society 2023-04 2023-03-31 /pmc/articles/PMC10083344/ /pubmed/37051154 http://dx.doi.org/10.4174/astr.2023.104.4.183 Text en Copyright © 2023, the Korean Surgical Society https://creativecommons.org/licenses/by-nc/4.0/Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Gang, Sujin
Choi, YoungRok
Lee, Boram
Yoon, Kyung Chul
Hong, Su young
Suh, Sanggyun
Han, Eui Soo
Hong, Suk Kyun
Lee, Hae Won
Cho, Jai Young
Yi, Nam-joon
Lee, Kwang-Woong
Suh, Kyung-Suk
Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study
title Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study
title_full Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study
title_fullStr Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study
title_full_unstemmed Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study
title_short Long-term outcomes of liver transplantation using grafts from donors with active hepatitis B virus replication: a multicenter cohort study
title_sort long-term outcomes of liver transplantation using grafts from donors with active hepatitis b virus replication: a multicenter cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083344/
https://www.ncbi.nlm.nih.gov/pubmed/37051154
http://dx.doi.org/10.4174/astr.2023.104.4.183
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