Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases

Proton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and infla...

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Autores principales: Räisänen, Laura, Viljakainen, Heli, Kolho, Kaija-Leena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083351/
https://www.ncbi.nlm.nih.gov/pubmed/37051434
http://dx.doi.org/10.3389/fped.2023.1157547
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author Räisänen, Laura
Viljakainen, Heli
Kolho, Kaija-Leena
author_facet Räisänen, Laura
Viljakainen, Heli
Kolho, Kaija-Leena
author_sort Räisänen, Laura
collection PubMed
description Proton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD). We investigated whether PPIs are associated with the development of ADs in children and concluded that PPI exposures could be related to the onset of ADs, especially IBD and potentially AIT as well.
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spelling pubmed-100833512023-04-11 Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases Räisänen, Laura Viljakainen, Heli Kolho, Kaija-Leena Front Pediatr Pediatrics Proton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD). We investigated whether PPIs are associated with the development of ADs in children and concluded that PPI exposures could be related to the onset of ADs, especially IBD and potentially AIT as well. Frontiers Media S.A. 2023-03-27 /pmc/articles/PMC10083351/ /pubmed/37051434 http://dx.doi.org/10.3389/fped.2023.1157547 Text en © 2023 Räisänen, Viljakainen and Kolho. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Räisänen, Laura
Viljakainen, Heli
Kolho, Kaija-Leena
Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases
title Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases
title_full Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases
title_fullStr Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases
title_full_unstemmed Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases
title_short Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases
title_sort exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083351/
https://www.ncbi.nlm.nih.gov/pubmed/37051434
http://dx.doi.org/10.3389/fped.2023.1157547
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