Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na(V)1.7

Gain-of-function mutations in voltage-gated sodium channel Na(V)1.7 cause severe inherited pain syndromes, including inherited erythromelalgia (IEM). The structural basis of these disease mutations, however, remains elusive. Here, we focused on three mutations that all substitute threonine residues...

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Detalles Bibliográficos
Autores principales: Wisedchaisri, Goragot, Gamal El-Din, Tamer M., Zheng, Ning, Catterall, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083536/
https://www.ncbi.nlm.nih.gov/pubmed/36996107
http://dx.doi.org/10.1073/pnas.2219624120

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