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Disruption of energetic and dynamic base pairing cooperativity in DNA duplexes by an abasic site
DNA duplex stability arises from cooperative interactions between multiple adjacent nucleotides that favor base pairing and stacking when formed as a continuous stretch rather than individually. Lesions and nucleobase modifications alter this stability in complex manners that remain challenging to u...
Autores principales: | Ashwood, Brennan, Jones, Michael S., Ferguson, Andrew L., Tokmakoff, Andrei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083564/ https://www.ncbi.nlm.nih.gov/pubmed/36976762 http://dx.doi.org/10.1073/pnas.2219124120 |
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