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Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells
Cells respond to stress by synthesizing chaperone proteins that seek to correct protein misfolding and maintain function. However, abrogation of protein homeostasis is a hallmark of aging, leading to loss of function and the formation of proteotoxic aggregates characteristic of pathology. Consequent...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083568/ https://www.ncbi.nlm.nih.gov/pubmed/36989307 http://dx.doi.org/10.1073/pnas.2210745120 |