Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion

Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can result in poor in vivo function, a phenomenon termed exhaustion. Whether or not Tregs are also susceptible to exhaustion, and if s...

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Detalles Bibliográficos
Autores principales: Lamarche, Caroline, Ward-Hartstonge, Kirsten, Mi, Tian, Lin, David T. S., Huang, Qing, Brown, Andrew, Edwards, Karlie, Novakovsky, Gherman E., Qi, Christopher N., Kobor, Michael S., Zebley, Caitlin C., Weber, Evan W., Mackall, Crystal L., Levings, Megan K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083618/
https://www.ncbi.nlm.nih.gov/pubmed/36972454
http://dx.doi.org/10.1073/pnas.2219086120

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