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Outcome of COVID-19 infections in patients with adrenal insufficiency and excess

BACKGROUND: Information on clinical outcomes of coronavirus disease 19 (COVID-19) infection in patients with adrenal disorders is scarce. METHODS: A collaboration between the European Society of Endocrinology (ESE) Rare Disease Committee and European Reference Network on Rare Endocrine Conditions vi...

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Autores principales: Nowotny, Hanna F, Bryce, Jillian, Ali, Salma R, Giordano, Roberta, Baronio, Federico, Chifu, Irina, Tschaidse, Lea, Cools, Martine, van den Akker, Erica LT, Falhammar, Henrik, Appelman-Dijkstra, Natasha M, Persani, Luca, Beccuti, Guglielmo, Ross, Ian L, Grozinsky-Glasberg, Simona, Pereira, Alberto M, Husebye, Eystein S, Hahner, Stefanie, Faisal Ahmed, S, Reisch, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083676/
https://www.ncbi.nlm.nih.gov/pubmed/36715679
http://dx.doi.org/10.1530/EC-22-0416
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author Nowotny, Hanna F
Bryce, Jillian
Ali, Salma R
Giordano, Roberta
Baronio, Federico
Chifu, Irina
Tschaidse, Lea
Cools, Martine
van den Akker, Erica LT
Falhammar, Henrik
Appelman-Dijkstra, Natasha M
Persani, Luca
Beccuti, Guglielmo
Ross, Ian L
Grozinsky-Glasberg, Simona
Pereira, Alberto M
Husebye, Eystein S
Hahner, Stefanie
Faisal Ahmed, S
Reisch, Nicole
author_facet Nowotny, Hanna F
Bryce, Jillian
Ali, Salma R
Giordano, Roberta
Baronio, Federico
Chifu, Irina
Tschaidse, Lea
Cools, Martine
van den Akker, Erica LT
Falhammar, Henrik
Appelman-Dijkstra, Natasha M
Persani, Luca
Beccuti, Guglielmo
Ross, Ian L
Grozinsky-Glasberg, Simona
Pereira, Alberto M
Husebye, Eystein S
Hahner, Stefanie
Faisal Ahmed, S
Reisch, Nicole
author_sort Nowotny, Hanna F
collection PubMed
description BACKGROUND: Information on clinical outcomes of coronavirus disease 19 (COVID-19) infection in patients with adrenal disorders is scarce. METHODS: A collaboration between the European Society of Endocrinology (ESE) Rare Disease Committee and European Reference Network on Rare Endocrine Conditions via the European Registries for Rare Endocrine Conditions allowed the collection of data on 64 cases (57 adrenal insufficiency (AI), 7 Cushing’s syndrome) that had been reported by 12 centres in 8 European countries between January 2020 and December 2021. RESULTS: Of all 64 patients, 23 were males and 41 females (13 of those children) with a median age of 37 and 51 years. In 45/57 (95%) AI cases, COVID-19 infection was confirmed by testing. Primary insufficiency was present in 45/57 patients; 19 were affected by Addison’s disease, 19 by congenital adrenal hyperplasia and 7 by primary AI (PAI) due to other causes. The most relevant comorbidities were hypertension (12%), obesity (n = 14%) and diabetes mellitus (9%). An increase by a median of 2.0 (IQR 1.4) times the daily replacement dose was reported in 42 (74%) patients. Two patients were administered i.m. injection of 100 mg hydrocortisone, and 11/64 were admitted to the hospital. Two patients had to be transferred to the intensive care unit, one with a fatal outcome. Four patients reported persistent SARS-CoV-2 infection, all others complete remission. CONCLUSION: This European multicentre questionnaire is the first to collect data on the outcome of COVID-19 infection in patients with adrenal gland disorders. It suggests good clinical outcomes in case of duly dose adjustments and emphasizes the importance of patient education on sick day rules.
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spelling pubmed-100836762023-04-11 Outcome of COVID-19 infections in patients with adrenal insufficiency and excess Nowotny, Hanna F Bryce, Jillian Ali, Salma R Giordano, Roberta Baronio, Federico Chifu, Irina Tschaidse, Lea Cools, Martine van den Akker, Erica LT Falhammar, Henrik Appelman-Dijkstra, Natasha M Persani, Luca Beccuti, Guglielmo Ross, Ian L Grozinsky-Glasberg, Simona Pereira, Alberto M Husebye, Eystein S Hahner, Stefanie Faisal Ahmed, S Reisch, Nicole Endocr Connect Research BACKGROUND: Information on clinical outcomes of coronavirus disease 19 (COVID-19) infection in patients with adrenal disorders is scarce. METHODS: A collaboration between the European Society of Endocrinology (ESE) Rare Disease Committee and European Reference Network on Rare Endocrine Conditions via the European Registries for Rare Endocrine Conditions allowed the collection of data on 64 cases (57 adrenal insufficiency (AI), 7 Cushing’s syndrome) that had been reported by 12 centres in 8 European countries between January 2020 and December 2021. RESULTS: Of all 64 patients, 23 were males and 41 females (13 of those children) with a median age of 37 and 51 years. In 45/57 (95%) AI cases, COVID-19 infection was confirmed by testing. Primary insufficiency was present in 45/57 patients; 19 were affected by Addison’s disease, 19 by congenital adrenal hyperplasia and 7 by primary AI (PAI) due to other causes. The most relevant comorbidities were hypertension (12%), obesity (n = 14%) and diabetes mellitus (9%). An increase by a median of 2.0 (IQR 1.4) times the daily replacement dose was reported in 42 (74%) patients. Two patients were administered i.m. injection of 100 mg hydrocortisone, and 11/64 were admitted to the hospital. Two patients had to be transferred to the intensive care unit, one with a fatal outcome. Four patients reported persistent SARS-CoV-2 infection, all others complete remission. CONCLUSION: This European multicentre questionnaire is the first to collect data on the outcome of COVID-19 infection in patients with adrenal gland disorders. It suggests good clinical outcomes in case of duly dose adjustments and emphasizes the importance of patient education on sick day rules. Bioscientifica Ltd 2023-01-26 /pmc/articles/PMC10083676/ /pubmed/36715679 http://dx.doi.org/10.1530/EC-22-0416 Text en © the author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research
Nowotny, Hanna F
Bryce, Jillian
Ali, Salma R
Giordano, Roberta
Baronio, Federico
Chifu, Irina
Tschaidse, Lea
Cools, Martine
van den Akker, Erica LT
Falhammar, Henrik
Appelman-Dijkstra, Natasha M
Persani, Luca
Beccuti, Guglielmo
Ross, Ian L
Grozinsky-Glasberg, Simona
Pereira, Alberto M
Husebye, Eystein S
Hahner, Stefanie
Faisal Ahmed, S
Reisch, Nicole
Outcome of COVID-19 infections in patients with adrenal insufficiency and excess
title Outcome of COVID-19 infections in patients with adrenal insufficiency and excess
title_full Outcome of COVID-19 infections in patients with adrenal insufficiency and excess
title_fullStr Outcome of COVID-19 infections in patients with adrenal insufficiency and excess
title_full_unstemmed Outcome of COVID-19 infections in patients with adrenal insufficiency and excess
title_short Outcome of COVID-19 infections in patients with adrenal insufficiency and excess
title_sort outcome of covid-19 infections in patients with adrenal insufficiency and excess
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083676/
https://www.ncbi.nlm.nih.gov/pubmed/36715679
http://dx.doi.org/10.1530/EC-22-0416
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