In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamsters

BACKGROUND: The SARS-CoV-2 delta (B.1.617.2 lineage) variant was first identified at the end of 2020 and possessed two unique amino acid substitutions in its spike protein: S-P681R, at the S1/S2 cleavage site, and S-D950N, in the HR1 of the S2 subunit. However, the roles of these substitutions in vi...

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Detalles Bibliográficos
Autores principales: Furusawa, Yuri, Kiso, Maki, Iida, Shun, Uraki, Ryuta, Hirata, Yuichiro, Imai, Masaki, Suzuki, Tadaki, Yamayoshi, Seiya, Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083686/
https://www.ncbi.nlm.nih.gov/pubmed/37043872
http://dx.doi.org/10.1016/j.ebiom.2023.104561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083686/
https://www.ncbi.nlm.nih.gov/pubmed/37043872
http://dx.doi.org/10.1016/j.ebiom.2023.104561

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