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Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer

BACKGROUND: High-grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic malignancy characterized by resistance to chemotherapy and high rates of recurrence. HGSC tumors display a high prevalence of tumor suppressor gene loss. Given the type 1 interferon regulatory function of BRCA1 and...

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Detalles Bibliográficos
Autores principales:	Shakfa, Noor, Li, Deyang, Conseil, Gwenaelle, Lightbody, Elizabeth D, Wilson-Sanchez, Juliette, Hamade, Ali, Chenard, Stephen, Jawa, Natasha A., Laight, Brian J., Afriyie-Asante, Afrakoma, Tyryshkin, Kathrin, Koebel, Martin, Koti, Madhuri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083863/ https://www.ncbi.nlm.nih.gov/pubmed/37015760 http://dx.doi.org/10.1136/jitc-2022-006170

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