Engineering second-generation TCR-T cells by site-specific integration of TRAF-binding motifs into the CD247 locus

BACKGROUND: The incorporation of co-stimulatory signaling domains into second-generation chimeric antigen receptors (CARs) significantly enhances the proliferation and persistence of CAR-T cells in vivo, leading to successful clinical outcomes. METHODS: To achieve such functional enhancement in tran...

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Detalles Bibliográficos
Autores principales: Lah, Sangjoon, Kim, Segi, Kang, In, Kim, Hyojin, Hupperetz, Cedric, Jung, Hyuncheol, Choi, Hyeong Ryeol, Lee, Young-Ho, Jang, Hyeon-Ki, Bae, Sangsu, Kim, Chan Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083865/
https://www.ncbi.nlm.nih.gov/pubmed/37019470
http://dx.doi.org/10.1136/jitc-2022-005519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083865/
https://www.ncbi.nlm.nih.gov/pubmed/37019470
http://dx.doi.org/10.1136/jitc-2022-005519

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