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Multiple CD59 Polymorphisms in Chinese Patients with Mycobacterium tuberculosis Infection
METHODS: A case–control study was conducted to investigate the SNPs at CD59 rs1047581, rs7046, rs2231460, rs184251026, rs41275164, rs831633, rs704700, rs41275166, and rs10768024 by sequence-specific primer-polymerase chain reaction (SSP-PCR) in 900 tuberculosis patients and 1,534 controls. RESULTS:...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083888/ https://www.ncbi.nlm.nih.gov/pubmed/37050931 http://dx.doi.org/10.1155/2023/1216048 |
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author | Tang, Jie Zhao, Zhenzhen Zhou, Juan Jiao, Lin Zhou, Wenjing Ying, Binwu Yang, Yuwei |
author_facet | Tang, Jie Zhao, Zhenzhen Zhou, Juan Jiao, Lin Zhou, Wenjing Ying, Binwu Yang, Yuwei |
author_sort | Tang, Jie |
collection | PubMed |
description | METHODS: A case–control study was conducted to investigate the SNPs at CD59 rs1047581, rs7046, rs2231460, rs184251026, rs41275164, rs831633, rs704700, rs41275166, and rs10768024 by sequence-specific primer-polymerase chain reaction (SSP-PCR) in 900 tuberculosis patients and 1,534 controls. RESULTS: The minor allele frequencies at rs2231460, rs184251026, rs41275164, and rs41275166 were extremely low both in the Cases (0.00%–0.61%) and in the Controls (0.07%–0.43%), comparatively at rs1047581, rs7046, rs831633, rs704700, and rs10768024 were notably higher both in the Cases (8.23%–48.39%) and in the Controls (8.57%–47.16%). Among the nine SNPs, only homozygous CC genotype at rs10768024 showed a significant protective effect against TB than homozygous TT genotype (OR(95% CI) = 0.59(0.38, 0.91), χ(2) = 5.779, P = 0.016), and homozygous TT and heterozygous CT genotypes showed a significant risk of TB infection in the recessive model (OR(95% CI) = 1.68(1.10, 2.56), χ(2) = 5.769, P = 0.016). Further analysis verified that rs10768024 CC genotype independently related to TB susceptibility (OR(95% CI) = 0.60(0.39, 0.91), Wald χ(2) = 5.664, P = 0.017) in multivariate logistic regression analysis, and its genetic mutation was independent of the other SNPs (r(2) = 0.00–0.20) in haplotype analysis. CONCLUSIONS: The first investigation of the CD59 gene and susceptibility to TB suggests a significant risk with homozygous TT and heterozygous CT genotypes at rs10768024 loci. The homozygous CC mutation at rs10768024 loci showed a significant protection against TB susceptibility. |
format | Online Article Text |
id | pubmed-10083888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-100838882023-04-11 Multiple CD59 Polymorphisms in Chinese Patients with Mycobacterium tuberculosis Infection Tang, Jie Zhao, Zhenzhen Zhou, Juan Jiao, Lin Zhou, Wenjing Ying, Binwu Yang, Yuwei J Immunol Res Research Article METHODS: A case–control study was conducted to investigate the SNPs at CD59 rs1047581, rs7046, rs2231460, rs184251026, rs41275164, rs831633, rs704700, rs41275166, and rs10768024 by sequence-specific primer-polymerase chain reaction (SSP-PCR) in 900 tuberculosis patients and 1,534 controls. RESULTS: The minor allele frequencies at rs2231460, rs184251026, rs41275164, and rs41275166 were extremely low both in the Cases (0.00%–0.61%) and in the Controls (0.07%–0.43%), comparatively at rs1047581, rs7046, rs831633, rs704700, and rs10768024 were notably higher both in the Cases (8.23%–48.39%) and in the Controls (8.57%–47.16%). Among the nine SNPs, only homozygous CC genotype at rs10768024 showed a significant protective effect against TB than homozygous TT genotype (OR(95% CI) = 0.59(0.38, 0.91), χ(2) = 5.779, P = 0.016), and homozygous TT and heterozygous CT genotypes showed a significant risk of TB infection in the recessive model (OR(95% CI) = 1.68(1.10, 2.56), χ(2) = 5.769, P = 0.016). Further analysis verified that rs10768024 CC genotype independently related to TB susceptibility (OR(95% CI) = 0.60(0.39, 0.91), Wald χ(2) = 5.664, P = 0.017) in multivariate logistic regression analysis, and its genetic mutation was independent of the other SNPs (r(2) = 0.00–0.20) in haplotype analysis. CONCLUSIONS: The first investigation of the CD59 gene and susceptibility to TB suggests a significant risk with homozygous TT and heterozygous CT genotypes at rs10768024 loci. The homozygous CC mutation at rs10768024 loci showed a significant protection against TB susceptibility. Hindawi 2023-04-02 /pmc/articles/PMC10083888/ /pubmed/37050931 http://dx.doi.org/10.1155/2023/1216048 Text en Copyright © 2023 Jie Tang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tang, Jie Zhao, Zhenzhen Zhou, Juan Jiao, Lin Zhou, Wenjing Ying, Binwu Yang, Yuwei Multiple CD59 Polymorphisms in Chinese Patients with Mycobacterium tuberculosis Infection |
title | Multiple CD59 Polymorphisms in Chinese Patients with Mycobacterium tuberculosis Infection |
title_full | Multiple CD59 Polymorphisms in Chinese Patients with Mycobacterium tuberculosis Infection |
title_fullStr | Multiple CD59 Polymorphisms in Chinese Patients with Mycobacterium tuberculosis Infection |
title_full_unstemmed | Multiple CD59 Polymorphisms in Chinese Patients with Mycobacterium tuberculosis Infection |
title_short | Multiple CD59 Polymorphisms in Chinese Patients with Mycobacterium tuberculosis Infection |
title_sort | multiple cd59 polymorphisms in chinese patients with mycobacterium tuberculosis infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083888/ https://www.ncbi.nlm.nih.gov/pubmed/37050931 http://dx.doi.org/10.1155/2023/1216048 |
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