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Candida species isolated from clinical samples in a tertiary hospital in Honduras: Where is Candida auris?

BACKGROUND AND PURPOSE: Infections by emerging and multiresistant Candida species are becoming more frequent throughout the world. This study aimed to describe Candida species in different wards of a tertiary hospital in Honduras. MATERIALS AND METHODS: The prevalence of species within the C. albica...

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Detalles Bibliográficos
Autores principales: Ortiz, Bryan, Aguilar, Kateryn, Galindo, Celeste, Molina, Lizzy, Fontecha, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Medical Mycology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084484/
https://www.ncbi.nlm.nih.gov/pubmed/37051554
http://dx.doi.org/10.18502/cmm.8.3.11212
Descripción
Sumario:BACKGROUND AND PURPOSE: Infections by emerging and multiresistant Candida species are becoming more frequent throughout the world. This study aimed to describe Candida species in different wards of a tertiary hospital in Honduras. MATERIALS AND METHODS: The prevalence of species within the C. albicans complex was estimated using a molecular approach, and C. auris was investigated using a yeast pool-based DNA extraction method. In total, 328 yeast isolates were identified using phenotypic approaches. For the identification of species within the C. albicans complex, a molecular approach based on the size polymorphisms of the hpw1 gene was used. In addition, a technique was optimized based on DNA extraction in pools for the rapid identification of C. auris. RESULTS: A total of 11 species of Candida were identified in the hospital wards. C. albicans showed the highest number of isolates (52.4%). Within the C. albicans complex, C. albicans sensu stricto was the most common, followed by C. dubliniensis. However, C. auris was not found. CONCLUSION: Reports on the distribution of Candida species in Honduras are limited; accordingly, the data from this study are of importance for a better understanding of their epidemiology. Moreover, a simple method was offered for the detection of C. auris that could help in its detection in low-resource settings.