Garcinia cambogia water extract alleviates insulin resistance and hepatic lipid accumulation in mice fed a high-fat diet

BACKGROUND: Garcinia cambogia is widely used as a weight-loss supplement, and it is reported to be negatively associated with metabolic diseases including insulin resistance (IR), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and dyslipidemia. OBJECTIVE: This study aime...

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Autores principales: Dong, Jinya, Li, Wen, Du, Xiaocui, He, Xiaofang, Deng, Bin, Zheng, Hongmei, Tian, Yang, Sheng, Jun, Fang, Chongye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Academia 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084504/
https://www.ncbi.nlm.nih.gov/pubmed/37050928
http://dx.doi.org/10.29219/fnr.v67.8977
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author Dong, Jinya
Li, Wen
Du, Xiaocui
He, Xiaofang
Deng, Bin
Zheng, Hongmei
Tian, Yang
Sheng, Jun
Fang, Chongye
author_facet Dong, Jinya
Li, Wen
Du, Xiaocui
He, Xiaofang
Deng, Bin
Zheng, Hongmei
Tian, Yang
Sheng, Jun
Fang, Chongye
author_sort Dong, Jinya
collection PubMed
description BACKGROUND: Garcinia cambogia is widely used as a weight-loss supplement, and it is reported to be negatively associated with metabolic diseases including insulin resistance (IR), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and dyslipidemia. OBJECTIVE: This study aimed to investigate the effect of G. cambogia water extract (GE) on high-fat diet (HFD)-induced obesity, IR, and hepatic lipid accumulation. DESIGN: C57BL/6 male mice were fed HFD with or without GE, GED and GEP for 16 weeks, and the mice were subjected to insulin tolerance tests and liver histological analysis. The hydroxycitric acid (HCA) levels of GE, GED, and GEP were measured by high-performance liquid chromatography. RESULTS: The results showed that GE significantly reduced HFD-induced body weight gain (P < 0.001), alleviated IR (P < 0.01), reduced serum total cholesterol (TC) (P < 0.001), and attenuated HFD-induced hepatic lipid accumulation. To investigate the constituent that was responsible for these effects, we separated GE into the component that dissolved in ethanol (GED) and the component that was precipitated by ethanol (GEP). Further mouse experiments showed that both GED and GEP were effective, but GED (which was used at a dose of 4 g/L) was more effective than GEP (which was used at a lower dose of 1 g/L). The HCA levels in GED and GEP were similar, although less than in GE. HCA may be the effective component in GE. CONCLUSION: This study provides evidence that G. cambogia can be used as a natural supplement to alleviate IR and hepatic lipid accumulation.
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spelling pubmed-100845042023-04-11 Garcinia cambogia water extract alleviates insulin resistance and hepatic lipid accumulation in mice fed a high-fat diet Dong, Jinya Li, Wen Du, Xiaocui He, Xiaofang Deng, Bin Zheng, Hongmei Tian, Yang Sheng, Jun Fang, Chongye Food Nutr Res Original Article BACKGROUND: Garcinia cambogia is widely used as a weight-loss supplement, and it is reported to be negatively associated with metabolic diseases including insulin resistance (IR), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and dyslipidemia. OBJECTIVE: This study aimed to investigate the effect of G. cambogia water extract (GE) on high-fat diet (HFD)-induced obesity, IR, and hepatic lipid accumulation. DESIGN: C57BL/6 male mice were fed HFD with or without GE, GED and GEP for 16 weeks, and the mice were subjected to insulin tolerance tests and liver histological analysis. The hydroxycitric acid (HCA) levels of GE, GED, and GEP were measured by high-performance liquid chromatography. RESULTS: The results showed that GE significantly reduced HFD-induced body weight gain (P < 0.001), alleviated IR (P < 0.01), reduced serum total cholesterol (TC) (P < 0.001), and attenuated HFD-induced hepatic lipid accumulation. To investigate the constituent that was responsible for these effects, we separated GE into the component that dissolved in ethanol (GED) and the component that was precipitated by ethanol (GEP). Further mouse experiments showed that both GED and GEP were effective, but GED (which was used at a dose of 4 g/L) was more effective than GEP (which was used at a lower dose of 1 g/L). The HCA levels in GED and GEP were similar, although less than in GE. HCA may be the effective component in GE. CONCLUSION: This study provides evidence that G. cambogia can be used as a natural supplement to alleviate IR and hepatic lipid accumulation. Open Academia 2023-03-14 /pmc/articles/PMC10084504/ /pubmed/37050928 http://dx.doi.org/10.29219/fnr.v67.8977 Text en © 2023 Jinya Dong et al. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license.
spellingShingle Original Article
Dong, Jinya
Li, Wen
Du, Xiaocui
He, Xiaofang
Deng, Bin
Zheng, Hongmei
Tian, Yang
Sheng, Jun
Fang, Chongye
Garcinia cambogia water extract alleviates insulin resistance and hepatic lipid accumulation in mice fed a high-fat diet
title Garcinia cambogia water extract alleviates insulin resistance and hepatic lipid accumulation in mice fed a high-fat diet
title_full Garcinia cambogia water extract alleviates insulin resistance and hepatic lipid accumulation in mice fed a high-fat diet
title_fullStr Garcinia cambogia water extract alleviates insulin resistance and hepatic lipid accumulation in mice fed a high-fat diet
title_full_unstemmed Garcinia cambogia water extract alleviates insulin resistance and hepatic lipid accumulation in mice fed a high-fat diet
title_short Garcinia cambogia water extract alleviates insulin resistance and hepatic lipid accumulation in mice fed a high-fat diet
title_sort garcinia cambogia water extract alleviates insulin resistance and hepatic lipid accumulation in mice fed a high-fat diet
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084504/
https://www.ncbi.nlm.nih.gov/pubmed/37050928
http://dx.doi.org/10.29219/fnr.v67.8977
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