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Observational Study Examining Kidney Transplantation Outcomes Following Donation From Individuals That Died of Drug Toxicity in British Columbia, Canada

BACKGROUND: The illicit drug toxicity (overdose) crisis has worsened across Canada, between 2016 and 2021 more than 28 000 individuals have died of drug toxicity. Organ donation from persons who experience drug toxicity death has increased in recent years. OBJECTIVE: This study examines whether graf...

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Autores principales: Xie, Max Wenheng, Kennan, Sean Patrick, Slaunwhite, Amanda, Rose, Caren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084533/
https://www.ncbi.nlm.nih.gov/pubmed/37051047
http://dx.doi.org/10.1177/20543581231156853
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author Xie, Max Wenheng
Kennan, Sean Patrick
Slaunwhite, Amanda
Rose, Caren
author_facet Xie, Max Wenheng
Kennan, Sean Patrick
Slaunwhite, Amanda
Rose, Caren
author_sort Xie, Max Wenheng
collection PubMed
description BACKGROUND: The illicit drug toxicity (overdose) crisis has worsened across Canada, between 2016 and 2021 more than 28 000 individuals have died of drug toxicity. Organ donation from persons who experience drug toxicity death has increased in recent years. OBJECTIVE: This study examines whether graft loss after kidney transplantation differed by donor cause of death. DESIGN: Retrospective cohort. SETTING: Provincial transplant program of British Columbia, Canada. PATIENTS: Transplant recipients who received kidney transplantation from deceased donors aged 12 to 70 years between 2013 and 2019 (N = 1012). MEASUREMENTS: Transplant recipient all cause graft loss (graft loss due to any cause including death) was compared by donor cause of death from drug toxicity or other. METHODS: Five-year Kaplan-Meier estimates of all-cause graft survival, and 3-year complete as well as stratified inverse probability of treatment weighted Cox proportional hazards models were conducted. RESULTS: Drug toxicity death donors donated to 25% (252/1012) of kidney transplantations. Drug toxicity death donors were more likely to be young, white, males, with fewer comorbidities such as diabetes or hypertension but were more likely to have a terminal serum creatinine ≥1.5 mg/dL or be hepatitis C virus (HCV) positive. Unadjusted 5-year estimate of all-cause graft survival was 97% for recipients of drug toxicity donor kidneys and 83% for recipients of non-drug toxicity donor kidneys (P < .001). Recipients of drug toxicity death donor kidneys had decreased risk of all cause graft loss compared to recipients of non-drug toxicity death donor kidneys (hazard ratio [HR]: 0.30, 95% confidence interval [CI]: 0.12-0.77, P = .012). This is primarily due to the reduced risk of all-cause graft loss for recipients of younger (≤35 years) drug toxicity death donor kidneys (HR: 0.05, 95% CI: 0.00-0.55, P = .015). LIMITATIONS: Potential selection bias, potential unmeasured confounding. CONCLUSIONS: Donation after drug toxicity death is safe and should be considered more broadly to increase deceased donor kidney donation.
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spelling pubmed-100845332023-04-11 Observational Study Examining Kidney Transplantation Outcomes Following Donation From Individuals That Died of Drug Toxicity in British Columbia, Canada Xie, Max Wenheng Kennan, Sean Patrick Slaunwhite, Amanda Rose, Caren Can J Kidney Health Dis Original Clinical Research Quantitative BACKGROUND: The illicit drug toxicity (overdose) crisis has worsened across Canada, between 2016 and 2021 more than 28 000 individuals have died of drug toxicity. Organ donation from persons who experience drug toxicity death has increased in recent years. OBJECTIVE: This study examines whether graft loss after kidney transplantation differed by donor cause of death. DESIGN: Retrospective cohort. SETTING: Provincial transplant program of British Columbia, Canada. PATIENTS: Transplant recipients who received kidney transplantation from deceased donors aged 12 to 70 years between 2013 and 2019 (N = 1012). MEASUREMENTS: Transplant recipient all cause graft loss (graft loss due to any cause including death) was compared by donor cause of death from drug toxicity or other. METHODS: Five-year Kaplan-Meier estimates of all-cause graft survival, and 3-year complete as well as stratified inverse probability of treatment weighted Cox proportional hazards models were conducted. RESULTS: Drug toxicity death donors donated to 25% (252/1012) of kidney transplantations. Drug toxicity death donors were more likely to be young, white, males, with fewer comorbidities such as diabetes or hypertension but were more likely to have a terminal serum creatinine ≥1.5 mg/dL or be hepatitis C virus (HCV) positive. Unadjusted 5-year estimate of all-cause graft survival was 97% for recipients of drug toxicity donor kidneys and 83% for recipients of non-drug toxicity donor kidneys (P < .001). Recipients of drug toxicity death donor kidneys had decreased risk of all cause graft loss compared to recipients of non-drug toxicity death donor kidneys (hazard ratio [HR]: 0.30, 95% confidence interval [CI]: 0.12-0.77, P = .012). This is primarily due to the reduced risk of all-cause graft loss for recipients of younger (≤35 years) drug toxicity death donor kidneys (HR: 0.05, 95% CI: 0.00-0.55, P = .015). LIMITATIONS: Potential selection bias, potential unmeasured confounding. CONCLUSIONS: Donation after drug toxicity death is safe and should be considered more broadly to increase deceased donor kidney donation. SAGE Publications 2023-04-04 /pmc/articles/PMC10084533/ /pubmed/37051047 http://dx.doi.org/10.1177/20543581231156853 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Clinical Research Quantitative
Xie, Max Wenheng
Kennan, Sean Patrick
Slaunwhite, Amanda
Rose, Caren
Observational Study Examining Kidney Transplantation Outcomes Following Donation From Individuals That Died of Drug Toxicity in British Columbia, Canada
title Observational Study Examining Kidney Transplantation Outcomes Following Donation From Individuals That Died of Drug Toxicity in British Columbia, Canada
title_full Observational Study Examining Kidney Transplantation Outcomes Following Donation From Individuals That Died of Drug Toxicity in British Columbia, Canada
title_fullStr Observational Study Examining Kidney Transplantation Outcomes Following Donation From Individuals That Died of Drug Toxicity in British Columbia, Canada
title_full_unstemmed Observational Study Examining Kidney Transplantation Outcomes Following Donation From Individuals That Died of Drug Toxicity in British Columbia, Canada
title_short Observational Study Examining Kidney Transplantation Outcomes Following Donation From Individuals That Died of Drug Toxicity in British Columbia, Canada
title_sort observational study examining kidney transplantation outcomes following donation from individuals that died of drug toxicity in british columbia, canada
topic Original Clinical Research Quantitative
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084533/
https://www.ncbi.nlm.nih.gov/pubmed/37051047
http://dx.doi.org/10.1177/20543581231156853
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