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SARS-CoV-2 polyprotein substrate regulates the stepwise M(pro) cleavage reaction

The processing of the Coronavirus polyproteins pp1a and pp1ab by the main protease M(pro) to produce mature proteins is a crucial event in virus replication and a promising target for antiviral drug development. M(pro) cleaves polyproteins in a defined order, but how M(pro) and/or the polyproteins d...

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Detalles Bibliográficos
Autores principales:	Narwal, Manju, Armache, Jean-Paul, Edwards, Thomas J., Murakami, Katsuhiko S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084705/ https://www.ncbi.nlm.nih.gov/pubmed/37044215 http://dx.doi.org/10.1016/j.jbc.2023.104697

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