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New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape

The eukaryotic translation initiation factor 5A1 (eIF5A1) and 5A2 (eIF5A2) are important proteins in a variety of physiological and pathophysiological processes and their function has been linked to neurodevelopmental disorders, cancer, and viral infections. Here, we report two new genome-edited mou...

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Detalles Bibliográficos
Autores principales:	Schultz, Chad R., Sheldon, Ryan D., Xie, Huirong, Demireva, Elena Y., Uhl, Katie L., Agnew, Dalen W., Geerts, Dirk, Bachmann, André S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084858/ https://www.ncbi.nlm.nih.gov/pubmed/36848144 http://dx.doi.org/10.1242/bio.059647

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