Cargando…

MACC1-induced migration in tumors: Current state and perspective

Malignant tumors are still a global, heavy health burden. Many tumor types cannot be treated curatively, underlining the need for new treatment targets. In recent years, metastasis associated in colon cancer 1 (MACC1) was identified as a promising biomarker and drug target, as it is promoting tumor...

Descripción completa

Detalles Bibliográficos
Autores principales: Hohmann, Tim, Hohmann, Urszula, Dehghani, Faramarz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084939/
https://www.ncbi.nlm.nih.gov/pubmed/37051546
http://dx.doi.org/10.3389/fonc.2023.1165676
_version_ 1785021829745737728
author Hohmann, Tim
Hohmann, Urszula
Dehghani, Faramarz
author_facet Hohmann, Tim
Hohmann, Urszula
Dehghani, Faramarz
author_sort Hohmann, Tim
collection PubMed
description Malignant tumors are still a global, heavy health burden. Many tumor types cannot be treated curatively, underlining the need for new treatment targets. In recent years, metastasis associated in colon cancer 1 (MACC1) was identified as a promising biomarker and drug target, as it is promoting tumor migration, initiation, proliferation, and others in a multitude of solid cancers. Here, we will summarize the current knowledge about MACC1-induced tumor cell migration with a special focus on the cytoskeletal and adhesive systems. In addition, a brief overview of several in vitro models used for the analysis of cell migration is given. In this context, we will point to issues with the currently most prevalent models used to study MACC1-dependent migration. Lastly, open questions about MACC1-dependent effects on tumor cell migration will be addressed.
format Online
Article
Text
id pubmed-10084939
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100849392023-04-11 MACC1-induced migration in tumors: Current state and perspective Hohmann, Tim Hohmann, Urszula Dehghani, Faramarz Front Oncol Oncology Malignant tumors are still a global, heavy health burden. Many tumor types cannot be treated curatively, underlining the need for new treatment targets. In recent years, metastasis associated in colon cancer 1 (MACC1) was identified as a promising biomarker and drug target, as it is promoting tumor migration, initiation, proliferation, and others in a multitude of solid cancers. Here, we will summarize the current knowledge about MACC1-induced tumor cell migration with a special focus on the cytoskeletal and adhesive systems. In addition, a brief overview of several in vitro models used for the analysis of cell migration is given. In this context, we will point to issues with the currently most prevalent models used to study MACC1-dependent migration. Lastly, open questions about MACC1-dependent effects on tumor cell migration will be addressed. Frontiers Media S.A. 2023-03-27 /pmc/articles/PMC10084939/ /pubmed/37051546 http://dx.doi.org/10.3389/fonc.2023.1165676 Text en Copyright © 2023 Hohmann, Hohmann and Dehghani https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Hohmann, Tim
Hohmann, Urszula
Dehghani, Faramarz
MACC1-induced migration in tumors: Current state and perspective
title MACC1-induced migration in tumors: Current state and perspective
title_full MACC1-induced migration in tumors: Current state and perspective
title_fullStr MACC1-induced migration in tumors: Current state and perspective
title_full_unstemmed MACC1-induced migration in tumors: Current state and perspective
title_short MACC1-induced migration in tumors: Current state and perspective
title_sort macc1-induced migration in tumors: current state and perspective
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084939/
https://www.ncbi.nlm.nih.gov/pubmed/37051546
http://dx.doi.org/10.3389/fonc.2023.1165676
work_keys_str_mv AT hohmanntim macc1inducedmigrationintumorscurrentstateandperspective
AT hohmannurszula macc1inducedmigrationintumorscurrentstateandperspective
AT dehghanifaramarz macc1inducedmigrationintumorscurrentstateandperspective