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MACC1-induced migration in tumors: Current state and perspective
Malignant tumors are still a global, heavy health burden. Many tumor types cannot be treated curatively, underlining the need for new treatment targets. In recent years, metastasis associated in colon cancer 1 (MACC1) was identified as a promising biomarker and drug target, as it is promoting tumor...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084939/ https://www.ncbi.nlm.nih.gov/pubmed/37051546 http://dx.doi.org/10.3389/fonc.2023.1165676 |
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author | Hohmann, Tim Hohmann, Urszula Dehghani, Faramarz |
author_facet | Hohmann, Tim Hohmann, Urszula Dehghani, Faramarz |
author_sort | Hohmann, Tim |
collection | PubMed |
description | Malignant tumors are still a global, heavy health burden. Many tumor types cannot be treated curatively, underlining the need for new treatment targets. In recent years, metastasis associated in colon cancer 1 (MACC1) was identified as a promising biomarker and drug target, as it is promoting tumor migration, initiation, proliferation, and others in a multitude of solid cancers. Here, we will summarize the current knowledge about MACC1-induced tumor cell migration with a special focus on the cytoskeletal and adhesive systems. In addition, a brief overview of several in vitro models used for the analysis of cell migration is given. In this context, we will point to issues with the currently most prevalent models used to study MACC1-dependent migration. Lastly, open questions about MACC1-dependent effects on tumor cell migration will be addressed. |
format | Online Article Text |
id | pubmed-10084939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100849392023-04-11 MACC1-induced migration in tumors: Current state and perspective Hohmann, Tim Hohmann, Urszula Dehghani, Faramarz Front Oncol Oncology Malignant tumors are still a global, heavy health burden. Many tumor types cannot be treated curatively, underlining the need for new treatment targets. In recent years, metastasis associated in colon cancer 1 (MACC1) was identified as a promising biomarker and drug target, as it is promoting tumor migration, initiation, proliferation, and others in a multitude of solid cancers. Here, we will summarize the current knowledge about MACC1-induced tumor cell migration with a special focus on the cytoskeletal and adhesive systems. In addition, a brief overview of several in vitro models used for the analysis of cell migration is given. In this context, we will point to issues with the currently most prevalent models used to study MACC1-dependent migration. Lastly, open questions about MACC1-dependent effects on tumor cell migration will be addressed. Frontiers Media S.A. 2023-03-27 /pmc/articles/PMC10084939/ /pubmed/37051546 http://dx.doi.org/10.3389/fonc.2023.1165676 Text en Copyright © 2023 Hohmann, Hohmann and Dehghani https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Hohmann, Tim Hohmann, Urszula Dehghani, Faramarz MACC1-induced migration in tumors: Current state and perspective |
title | MACC1-induced migration in tumors: Current state and perspective |
title_full | MACC1-induced migration in tumors: Current state and perspective |
title_fullStr | MACC1-induced migration in tumors: Current state and perspective |
title_full_unstemmed | MACC1-induced migration in tumors: Current state and perspective |
title_short | MACC1-induced migration in tumors: Current state and perspective |
title_sort | macc1-induced migration in tumors: current state and perspective |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084939/ https://www.ncbi.nlm.nih.gov/pubmed/37051546 http://dx.doi.org/10.3389/fonc.2023.1165676 |
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