Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques

HIV-associated neurocognitive disorders (HAND) affect ~40% of virally suppressed people with HIV (PWH), however, the precise viral dependent and independent changes to the brain are unclear. Here we characterized the CNS reservoir and immune environment of SIV-infected (SIV+) rhesus macaques during...

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Detalles Bibliográficos
Autores principales: Byrnes, Sarah J., Busman-Sahay, Kathleen, Angelovich, Thomas A., Younger, Skyler, Taylor-Brill, Sol, Nekorchuk, Michael, Bondoc, Stephen, Dannay, Rachel, Terry, Margaret, Cochrane, Catherine R., Jenkins, Trisha A., Roche, Michael, Deleage, Claire, Bosinger, Steven E., Paiardini, Mirko, Brew, Bruce J., Estes, Jacob D., Churchill, Melissa J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085024/
https://www.ncbi.nlm.nih.gov/pubmed/36989320
http://dx.doi.org/10.1371/journal.ppat.1011290

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