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Diverse role of NMDA receptors for dendritic integration of neural dynamics
Neurons, represented as a tree structure of morphology, have various distinguished branches of dendrites. Different types of synaptic receptors distributed over dendrites are responsible for receiving inputs from other neurons. NMDA receptors (NMDARs) are expressed as excitatory units, and play a ke...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085026/ https://www.ncbi.nlm.nih.gov/pubmed/37036844 http://dx.doi.org/10.1371/journal.pcbi.1011019 |
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author | Tang, Yuanhong Zhang, Xingyu An, Lingling Yu, Zhaofei Liu, Jian K. |
author_facet | Tang, Yuanhong Zhang, Xingyu An, Lingling Yu, Zhaofei Liu, Jian K. |
author_sort | Tang, Yuanhong |
collection | PubMed |
description | Neurons, represented as a tree structure of morphology, have various distinguished branches of dendrites. Different types of synaptic receptors distributed over dendrites are responsible for receiving inputs from other neurons. NMDA receptors (NMDARs) are expressed as excitatory units, and play a key physiological role in synaptic function. Although NMDARs are widely expressed in most types of neurons, they play a different role in the cerebellar Purkinje cells (PCs). Utilizing a computational PC model with detailed dendritic morphology, we explored the role of NMDARs at different parts of dendritic branches and regions. We found somatic responses can switch from silent, to simple spikes and complex spikes, depending on specific dendritic branches. Detailed examination of the dendrites regarding their diameters and distance to soma revealed diverse response patterns, yet explain two firing modes, simple and complex spike. Taken together, these results suggest that NMDARs play an important role in controlling excitability sensitivity while taking into account the factor of dendritic properties. Given the complexity of neural morphology varying in cell types, our work suggests that the functional role of NMDARs is not stereotyped but highly interwoven with local properties of neuronal structure. |
format | Online Article Text |
id | pubmed-10085026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-100850262023-04-11 Diverse role of NMDA receptors for dendritic integration of neural dynamics Tang, Yuanhong Zhang, Xingyu An, Lingling Yu, Zhaofei Liu, Jian K. PLoS Comput Biol Research Article Neurons, represented as a tree structure of morphology, have various distinguished branches of dendrites. Different types of synaptic receptors distributed over dendrites are responsible for receiving inputs from other neurons. NMDA receptors (NMDARs) are expressed as excitatory units, and play a key physiological role in synaptic function. Although NMDARs are widely expressed in most types of neurons, they play a different role in the cerebellar Purkinje cells (PCs). Utilizing a computational PC model with detailed dendritic morphology, we explored the role of NMDARs at different parts of dendritic branches and regions. We found somatic responses can switch from silent, to simple spikes and complex spikes, depending on specific dendritic branches. Detailed examination of the dendrites regarding their diameters and distance to soma revealed diverse response patterns, yet explain two firing modes, simple and complex spike. Taken together, these results suggest that NMDARs play an important role in controlling excitability sensitivity while taking into account the factor of dendritic properties. Given the complexity of neural morphology varying in cell types, our work suggests that the functional role of NMDARs is not stereotyped but highly interwoven with local properties of neuronal structure. Public Library of Science 2023-04-10 /pmc/articles/PMC10085026/ /pubmed/37036844 http://dx.doi.org/10.1371/journal.pcbi.1011019 Text en © 2023 Tang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Tang, Yuanhong Zhang, Xingyu An, Lingling Yu, Zhaofei Liu, Jian K. Diverse role of NMDA receptors for dendritic integration of neural dynamics |
title | Diverse role of NMDA receptors for dendritic integration of neural dynamics |
title_full | Diverse role of NMDA receptors for dendritic integration of neural dynamics |
title_fullStr | Diverse role of NMDA receptors for dendritic integration of neural dynamics |
title_full_unstemmed | Diverse role of NMDA receptors for dendritic integration of neural dynamics |
title_short | Diverse role of NMDA receptors for dendritic integration of neural dynamics |
title_sort | diverse role of nmda receptors for dendritic integration of neural dynamics |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085026/ https://www.ncbi.nlm.nih.gov/pubmed/37036844 http://dx.doi.org/10.1371/journal.pcbi.1011019 |
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