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Inside-out: Antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9

Nsp9 is a conserved accessory component of the coronaviral replication and transcription complex. It is the predominant substrate of nsp12’s nucleotidylation activity while also serving to recruit proteins required for viral 5’-capping. Anti-nsp9 specific nanobodies have been isolated previously. We...

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Detalles Bibliográficos
Autores principales:	Pan, Yue, Chandrashekaran, Indu R., Tennant, Luke, Rossjohn, Jamie, Littler, Dene R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085042/ https://www.ncbi.nlm.nih.gov/pubmed/37036856 http://dx.doi.org/10.1371/journal.pone.0283194

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