EGFR endocytosis: more than meets the eye

Behind the scenes of signaling cascades initiated by activated receptors, endocytosis determines the fate of internalized proteins through degradation in lysosomes or recycling. Over the years, significant progress has been made in understanding the mechanisms of endocytosis and deregulation in dise...

Descripción completa

Detalles Bibliográficos
Autores principales: Sapmaz, Aysegul, Erson-Bensan, Ayse Elif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2023
Materias:
Editorial Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085055/
https://www.ncbi.nlm.nih.gov/pubmed/37036745
http://dx.doi.org/10.18632/oncotarget.28400
_version_ 1785021855521832960
author Sapmaz, Aysegul
Erson-Bensan, Ayse Elif
author_facet Sapmaz, Aysegul
Erson-Bensan, Ayse Elif
author_sort Sapmaz, Aysegul
collection PubMed
description Behind the scenes of signaling cascades initiated by activated receptors, endocytosis determines the fate of internalized proteins through degradation in lysosomes or recycling. Over the years, significant progress has been made in understanding the mechanisms of endocytosis and deregulation in disease states. Here we review the role of the EGF-SNX3-EGFR axis in breast cancers with an extended discussion on deregulated EGFR endocytosis in cancer.
format Online
Article
Text
id pubmed-10085055
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-100850552023-04-11 EGFR endocytosis: more than meets the eye Sapmaz, Aysegul Erson-Bensan, Ayse Elif Oncotarget Editorial Perspective Behind the scenes of signaling cascades initiated by activated receptors, endocytosis determines the fate of internalized proteins through degradation in lysosomes or recycling. Over the years, significant progress has been made in understanding the mechanisms of endocytosis and deregulation in disease states. Here we review the role of the EGF-SNX3-EGFR axis in breast cancers with an extended discussion on deregulated EGFR endocytosis in cancer. Impact Journals LLC 2023-04-10 /pmc/articles/PMC10085055/ /pubmed/37036745 http://dx.doi.org/10.18632/oncotarget.28400 Text en Copyright: © 2023 Sapmaz and Erson-Bensan. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Editorial Perspective
Sapmaz, Aysegul
Erson-Bensan, Ayse Elif
EGFR endocytosis: more than meets the eye
title EGFR endocytosis: more than meets the eye
title_full EGFR endocytosis: more than meets the eye
title_fullStr EGFR endocytosis: more than meets the eye
title_full_unstemmed EGFR endocytosis: more than meets the eye
title_short EGFR endocytosis: more than meets the eye
title_sort egfr endocytosis: more than meets the eye
topic Editorial Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085055/
https://www.ncbi.nlm.nih.gov/pubmed/37036745
http://dx.doi.org/10.18632/oncotarget.28400
work_keys_str_mv AT sapmazaysegul egfrendocytosismorethanmeetstheeye
AT ersonbensanayseelif egfrendocytosismorethanmeetstheeye

Ejemplares similares