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Determination of ultra-trace metal-protein interactions in co-formulated monoclonal antibody drug product by SEC-ICP-MS

Transition metals can be introduced in therapeutic protein drugs at various steps of the manufacturing process (e.g. manufacturing raw materials, formulation, storage), and can cause a variety of modifications on the protein. These modifications can potentially influence the efficacy, safety, and st...

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Detalles Bibliográficos
Autores principales:	Whitty-Léveillé, Laurence, VanAernum, Zachary L., Pavon, Jorge Alexander, Murphy, Christa, Neal, Katie, Forest, William, Gao, Xinliu, Zhong, Wendy, Richardson, Douglas D., Schuessler, Hillary A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085571/ https://www.ncbi.nlm.nih.gov/pubmed/37032437 http://dx.doi.org/10.1080/19420862.2023.2199466

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