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Promising antitumor effects of the curcumin analog DMC-BH on colorectal cancer cells
Colorectal cancer (CRC) is a common malignant tumor of the digestive system worldwide. DMC-BH, a curcumin analog, has been reported to possess anticancer properties against human gliomas. However, its effects and mechanism on CRC cells are still unknown. Our present study demonstrated that DMC-BH ha...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085616/ https://www.ncbi.nlm.nih.gov/pubmed/36971681 http://dx.doi.org/10.18632/aging.204610 |
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author | Liu, Gang Chen, Jian Bao, Zhicheng |
author_facet | Liu, Gang Chen, Jian Bao, Zhicheng |
author_sort | Liu, Gang |
collection | PubMed |
description | Colorectal cancer (CRC) is a common malignant tumor of the digestive system worldwide. DMC-BH, a curcumin analog, has been reported to possess anticancer properties against human gliomas. However, its effects and mechanism on CRC cells are still unknown. Our present study demonstrated that DMC-BH had stronger cytostatic ability than curcumin against CRC cells in vitro and in vivo. It effectively inhibited the proliferation and invasion and promoted the apoptosis of HCT116 and HT-29 cells. RNA-Seq and data analysis indicated that its effects might be mediated by regulation of the PI3K/AKT signaling. Western blotting further confirmed that it dose-dependently suppressed the phosphorylation of PI3K, AKT and mTOR. The Akt pathway activator SC79 reversed the proapoptotic effects of DMC-BH on CRC cells, indicating that its effects are mediated by PI3K/AKT/mTOR signaling. Collectively, the results of the present study suggest that DMC-BH exerts more potent effects than curcumin against CRC by inactivating the PI3K/AKT/mTOR signaling pathway. |
format | Online Article Text |
id | pubmed-10085616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-100856162023-04-11 Promising antitumor effects of the curcumin analog DMC-BH on colorectal cancer cells Liu, Gang Chen, Jian Bao, Zhicheng Aging (Albany NY) Research Paper Colorectal cancer (CRC) is a common malignant tumor of the digestive system worldwide. DMC-BH, a curcumin analog, has been reported to possess anticancer properties against human gliomas. However, its effects and mechanism on CRC cells are still unknown. Our present study demonstrated that DMC-BH had stronger cytostatic ability than curcumin against CRC cells in vitro and in vivo. It effectively inhibited the proliferation and invasion and promoted the apoptosis of HCT116 and HT-29 cells. RNA-Seq and data analysis indicated that its effects might be mediated by regulation of the PI3K/AKT signaling. Western blotting further confirmed that it dose-dependently suppressed the phosphorylation of PI3K, AKT and mTOR. The Akt pathway activator SC79 reversed the proapoptotic effects of DMC-BH on CRC cells, indicating that its effects are mediated by PI3K/AKT/mTOR signaling. Collectively, the results of the present study suggest that DMC-BH exerts more potent effects than curcumin against CRC by inactivating the PI3K/AKT/mTOR signaling pathway. Impact Journals 2023-03-24 /pmc/articles/PMC10085616/ /pubmed/36971681 http://dx.doi.org/10.18632/aging.204610 Text en Copyright: © 2023 Liu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Liu, Gang Chen, Jian Bao, Zhicheng Promising antitumor effects of the curcumin analog DMC-BH on colorectal cancer cells |
title | Promising antitumor effects of the curcumin analog DMC-BH on colorectal cancer cells |
title_full | Promising antitumor effects of the curcumin analog DMC-BH on colorectal cancer cells |
title_fullStr | Promising antitumor effects of the curcumin analog DMC-BH on colorectal cancer cells |
title_full_unstemmed | Promising antitumor effects of the curcumin analog DMC-BH on colorectal cancer cells |
title_short | Promising antitumor effects of the curcumin analog DMC-BH on colorectal cancer cells |
title_sort | promising antitumor effects of the curcumin analog dmc-bh on colorectal cancer cells |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085616/ https://www.ncbi.nlm.nih.gov/pubmed/36971681 http://dx.doi.org/10.18632/aging.204610 |
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