Cargando…
eEF1A2 siRNA Suppresses MPP(+)-Induced Activation of Akt and mTOR and Potentiates Caspase-3 Activation in a Parkinson's Disease Model
The tissue-specific protein eEF1A2 has been linked to the development of neurological disorders. The role of eEF1A2 in the pathogenesis of Parkinson's disease (PD) has yet to be investigated. The aim of this study was to determine the potential neuroprotective effects of eEF1A2 in an MPP(+) mod...
Autores principales: | Khwanraj, Kawinthra, Prommahom, Athinan, Dharmasaroja, Permphan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085650/ https://www.ncbi.nlm.nih.gov/pubmed/37051183 http://dx.doi.org/10.1155/2023/1335201 |
Ejemplares similares
-
Neuroblastoma Cell Death Induced by eEF1A2 Knockdown Is Possibly Mediated by the Inhibition of Akt and mTOR Phosphorylation
por: Khwanraj, Kawinthra, et al.
Publicado: (2021) -
Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson's Disease
por: Khwanraj, Kawinthra, et al.
Publicado: (2016) -
Evaluation of the Combination of Metformin and Rapamycin in an MPP(+)-Treated SH-SY5Y Model of Parkinson's Disease
por: Norradee, Chureerat, et al.
Publicado: (2023) -
Differential Expression of Tyrosine Hydroxylase Protein and Apoptosis-Related Genes in Differentiated and Undifferentiated SH-SY5Y Neuroblastoma Cells Treated with MPP(+)
por: Khwanraj, Kawinthra, et al.
Publicado: (2015) -
Downregulation of eEF1A/EFT3-4 Enhances Dopaminergic Neurodegeneration After 6-OHDA Exposure in C. elegans Model
por: Chalorak, Pawanrat, et al.
Publicado: (2020)