Crystal structures of the NAD(+)-II riboswitch reveal two distinct ligand-binding pockets

We present crystal structures of a new NAD(+)-binding riboswitch termed NAD(+)-II, bound to nicotinamide mononucleotide (NMN), nicotinamide adenine dinucleotide (NAD(+)) and nicotinamide riboside (NR). The RNA structure comprises a number of structural features including three helices, one of which...

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Detalles Bibliográficos
Autores principales: Peng, Xuemei, Liao, Wenjian, Lin, Xiaowei, Lilley, David M J, Huang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085692/
https://www.ncbi.nlm.nih.gov/pubmed/36840714
http://dx.doi.org/10.1093/nar/gkad102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085692/
https://www.ncbi.nlm.nih.gov/pubmed/36840714
http://dx.doi.org/10.1093/nar/gkad102

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