SPRTN-dependent DPC degradation precedes repair of damaged DNA: a proof of concept revealed by the STAR assay

DNA-protein crosslinks (DPCs), formed by the covalent conjugation of proteins to DNA, are toxic lesions that interfere with DNA metabolic processing and transcription. The development of an accurate biochemical assay for DPC isolation is a priority for the mechanistic understanding of their repair....

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Detalles Bibliográficos
Autores principales: Glumac, Mateo, Polović, Mirjana, Batel, Anja, Gelemanović, Andrea, Maček, Boris, Velić, Ana, Marinović-Terzić, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085693/
https://www.ncbi.nlm.nih.gov/pubmed/36718861
http://dx.doi.org/10.1093/nar/gkad022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085693/
https://www.ncbi.nlm.nih.gov/pubmed/36718861
http://dx.doi.org/10.1093/nar/gkad022

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