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Greedy reduction of Bacillus subtilis genome yields emergent phenotypes of high resistance to a DNA damaging agent and low evolvability

Genome-scale engineering enables rational removal of dispensable genes in chassis genomes. Deviating from this approach, we applied greedy accumulation of deletions of large dispensable regions in the Bacillus subtilis genome, yielding a library of 298 strains with genomes reduced up to 1.48 Mb in s...

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Detalles Bibliográficos
Autores principales:	Dervyn, Etienne, Planson, Anne-Gaëlle, Tanaka, Kosei, Chubukov, Victor, Guérin, Cyprien, Derozier, Sandra, Lecointe, François, Sauer, Uwe, Yoshida, Ken-Ichi, Nicolas, Pierre, Noirot, Philippe, Jules, Matthieu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Synthetic Biology and Bioengineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085710/ https://www.ncbi.nlm.nih.gov/pubmed/36919610 http://dx.doi.org/10.1093/nar/gkad145

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