Mast Cells and Resistance to Immunotherapy in Cancer

Mast cells are involved in tumor growth and their mediators exert both pro- and anti-tumorigenic roles in different human cancers. The identification of defined immunosuppressive pathways that are present in the tumor microenvironment has pointed therapeutic strategies that may promote inflammation...

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Detalles Bibliográficos
Autor principal: Ribatti, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085948/
https://www.ncbi.nlm.nih.gov/pubmed/37038035
http://dx.doi.org/10.1007/s00005-023-00676-x
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author Ribatti, Domenico
author_facet Ribatti, Domenico
author_sort Ribatti, Domenico
collection PubMed
description Mast cells are involved in tumor growth and their mediators exert both pro- and anti-tumorigenic roles in different human cancers. The identification of defined immunosuppressive pathways that are present in the tumor microenvironment has pointed therapeutic strategies that may promote inflammation and/or innate immune activation in this context. Mast cells can contribute to the immune suppressive tumor microenvironment and may also enhance anti-tumor responses. This review article is focused on the analysis of the mechanisms of the role of mast cells in resistance to immunotherapy in cancer.
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spelling pubmed-100859482023-04-12 Mast Cells and Resistance to Immunotherapy in Cancer Ribatti, Domenico Arch Immunol Ther Exp (Warsz) Review Mast cells are involved in tumor growth and their mediators exert both pro- and anti-tumorigenic roles in different human cancers. The identification of defined immunosuppressive pathways that are present in the tumor microenvironment has pointed therapeutic strategies that may promote inflammation and/or innate immune activation in this context. Mast cells can contribute to the immune suppressive tumor microenvironment and may also enhance anti-tumor responses. This review article is focused on the analysis of the mechanisms of the role of mast cells in resistance to immunotherapy in cancer. Springer International Publishing 2023-04-11 2023 /pmc/articles/PMC10085948/ /pubmed/37038035 http://dx.doi.org/10.1007/s00005-023-00676-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Ribatti, Domenico
Mast Cells and Resistance to Immunotherapy in Cancer
title Mast Cells and Resistance to Immunotherapy in Cancer
title_full Mast Cells and Resistance to Immunotherapy in Cancer
title_fullStr Mast Cells and Resistance to Immunotherapy in Cancer
title_full_unstemmed Mast Cells and Resistance to Immunotherapy in Cancer
title_short Mast Cells and Resistance to Immunotherapy in Cancer
title_sort mast cells and resistance to immunotherapy in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085948/
https://www.ncbi.nlm.nih.gov/pubmed/37038035
http://dx.doi.org/10.1007/s00005-023-00676-x
work_keys_str_mv AT ribattidomenico mastcellsandresistancetoimmunotherapyincancer

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