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Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography

Transcranial focused ultrasound stimulation is a promising therapeutic modality for human brain disorders because of its noninvasiveness, long penetration depth, and versatile spatial control capability through beamforming and beam steering. However, the skull presents a major hurdle for successful...

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Autores principales: Kook, Geon, Jo, Yehhyun, Oh, Chaerin, Liang, Xiaojia, Kim, Jaewon, Lee, Sang-Mok, Kim, Subeen, Choi, Jung-Woo, Lee, Hyunjoo Jenny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085992/
https://www.ncbi.nlm.nih.gov/pubmed/37056421
http://dx.doi.org/10.1038/s41378-023-00513-3
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author Kook, Geon
Jo, Yehhyun
Oh, Chaerin
Liang, Xiaojia
Kim, Jaewon
Lee, Sang-Mok
Kim, Subeen
Choi, Jung-Woo
Lee, Hyunjoo Jenny
author_facet Kook, Geon
Jo, Yehhyun
Oh, Chaerin
Liang, Xiaojia
Kim, Jaewon
Lee, Sang-Mok
Kim, Subeen
Choi, Jung-Woo
Lee, Hyunjoo Jenny
author_sort Kook, Geon
collection PubMed
description Transcranial focused ultrasound stimulation is a promising therapeutic modality for human brain disorders because of its noninvasiveness, long penetration depth, and versatile spatial control capability through beamforming and beam steering. However, the skull presents a major hurdle for successful applications of ultrasound stimulation. Specifically, skull-induced focal aberration limits the capability for accurate and versatile targeting of brain subregions. In addition, there lacks a fully functional preclinical neuromodulation system suitable to conduct behavioral studies. Here, we report a miniature ultrasound system for neuromodulation applications that is capable of highly accurate multiregion targeting based on acoustic holography. Our work includes the design and implementation of an acoustic lens for targeting brain regions with compensation for skull aberration through time-reversal recording and a phase conjugation mirror. Moreover, we utilize MEMS and 3D-printing technology to implement a 0.75-g lightweight neuromodulation system and present in vivo characterization of the packaged system in freely moving mice. This preclinical system is capable of accurately targeting the desired individual or multitude of brain regions, which will enable versatile and explorative behavior studies using ultrasound neuromodulation to facilitate widespread clinical adoption. [Image: see text]
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spelling pubmed-100859922023-04-12 Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography Kook, Geon Jo, Yehhyun Oh, Chaerin Liang, Xiaojia Kim, Jaewon Lee, Sang-Mok Kim, Subeen Choi, Jung-Woo Lee, Hyunjoo Jenny Microsyst Nanoeng Article Transcranial focused ultrasound stimulation is a promising therapeutic modality for human brain disorders because of its noninvasiveness, long penetration depth, and versatile spatial control capability through beamforming and beam steering. However, the skull presents a major hurdle for successful applications of ultrasound stimulation. Specifically, skull-induced focal aberration limits the capability for accurate and versatile targeting of brain subregions. In addition, there lacks a fully functional preclinical neuromodulation system suitable to conduct behavioral studies. Here, we report a miniature ultrasound system for neuromodulation applications that is capable of highly accurate multiregion targeting based on acoustic holography. Our work includes the design and implementation of an acoustic lens for targeting brain regions with compensation for skull aberration through time-reversal recording and a phase conjugation mirror. Moreover, we utilize MEMS and 3D-printing technology to implement a 0.75-g lightweight neuromodulation system and present in vivo characterization of the packaged system in freely moving mice. This preclinical system is capable of accurately targeting the desired individual or multitude of brain regions, which will enable versatile and explorative behavior studies using ultrasound neuromodulation to facilitate widespread clinical adoption. [Image: see text] Nature Publishing Group UK 2023-04-10 /pmc/articles/PMC10085992/ /pubmed/37056421 http://dx.doi.org/10.1038/s41378-023-00513-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kook, Geon
Jo, Yehhyun
Oh, Chaerin
Liang, Xiaojia
Kim, Jaewon
Lee, Sang-Mok
Kim, Subeen
Choi, Jung-Woo
Lee, Hyunjoo Jenny
Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography
title Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography
title_full Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography
title_fullStr Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography
title_full_unstemmed Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography
title_short Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography
title_sort multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10085992/
https://www.ncbi.nlm.nih.gov/pubmed/37056421
http://dx.doi.org/10.1038/s41378-023-00513-3
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