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TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

BACKGROUND AND AIMS: Major genomic drivers of hepatocellular carcinoma (HCC) are nowadays well recognized, although models to establish their roles in human HCC initiation remain scarce. Here, we used human liver organoids in experimental systems to mimic the early stages of human liver carcinogenes...

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Detalles Bibliográficos
Autores principales:	Lam, Yin Kau, Yu, Jianqing, Huang, Hao, Ding, Xiaofan, Wong, Alissa M., Leung, Howard H., Chan, Anthony W., Ng, Kelvin K., Xu, Mingjing, Wang, Xin, Wong, Nathalie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	Original Articles: Liver Cancer
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086078/ https://www.ncbi.nlm.nih.gov/pubmed/36221953 http://dx.doi.org/10.1002/hep.32802

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