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Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential
Ultra-conserved RNA (ucRNA) is a subset of long non-coding RNA, that is highly conserved among mice, rats and humans. UcRNA has attracted extensive attention in recent years for its potential biological significance in normal physiological function and diseases. However, due to the instability of RN...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086085/ https://www.ncbi.nlm.nih.gov/pubmed/37036543 http://dx.doi.org/10.1007/s12672-023-00650-1 |
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author | Wang, Tingye Li, Feng Lu, Zhanping |
author_facet | Wang, Tingye Li, Feng Lu, Zhanping |
author_sort | Wang, Tingye |
collection | PubMed |
description | Ultra-conserved RNA (ucRNA) is a subset of long non-coding RNA, that is highly conserved among mice, rats and humans. UcRNA has attracted extensive attention in recent years for its potential biological significance in normal physiological function and diseases. However, due to the instability of RNA and the technical limitation, the function and mechanism of ucRNAs are largely unknown. Over the last two decades, researchers have made a lot of efforts to try to lift the veil of ucRNA in nervous, cardiovascular system and other systems as well as cancers. Since the concept of the glymphatic system is relatively new, we summarized here recent findings on the functions, regulation and the underlying mechanisms of ucRNAs in physiology and pathology. Meanwhile, pathology in some diseases is likely to contribute to abnormal expression of ucRNA in turn. We also discuss the technical challenges and bright prospects for future applications of ucRNAs in the diagnosis and treatment of diseases. |
format | Online Article Text |
id | pubmed-10086085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-100860852023-04-12 Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential Wang, Tingye Li, Feng Lu, Zhanping Discov Oncol Review Ultra-conserved RNA (ucRNA) is a subset of long non-coding RNA, that is highly conserved among mice, rats and humans. UcRNA has attracted extensive attention in recent years for its potential biological significance in normal physiological function and diseases. However, due to the instability of RNA and the technical limitation, the function and mechanism of ucRNAs are largely unknown. Over the last two decades, researchers have made a lot of efforts to try to lift the veil of ucRNA in nervous, cardiovascular system and other systems as well as cancers. Since the concept of the glymphatic system is relatively new, we summarized here recent findings on the functions, regulation and the underlying mechanisms of ucRNAs in physiology and pathology. Meanwhile, pathology in some diseases is likely to contribute to abnormal expression of ucRNA in turn. We also discuss the technical challenges and bright prospects for future applications of ucRNAs in the diagnosis and treatment of diseases. Springer US 2023-04-10 /pmc/articles/PMC10086085/ /pubmed/37036543 http://dx.doi.org/10.1007/s12672-023-00650-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Wang, Tingye Li, Feng Lu, Zhanping Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential |
title | Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential |
title_full | Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential |
title_fullStr | Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential |
title_full_unstemmed | Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential |
title_short | Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential |
title_sort | ultra-conserved rna: a novel biological tool with diagnostic and therapeutic potential |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086085/ https://www.ncbi.nlm.nih.gov/pubmed/37036543 http://dx.doi.org/10.1007/s12672-023-00650-1 |
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