Immunologic and Autoimmune-Related Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Clinical Symptoms and Mechanisms of Disease

The COVID-19 pandemic has resulted in a significant number of people developing long-term health effects of postacute sequelae SARS-CoV-2 infection (PASC). Both acute COVID-19 and PASC are now recognized as multiorgan diseases with multiple symptoms and disease causes. The development of immune dysr...

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Autores principales: Ramasamy, Akshara, Wang, Chumeng, Brode, W. Michael, Verduzco-Gutierrez, Monica, Melamed, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086105/
https://www.ncbi.nlm.nih.gov/pubmed/37419536
http://dx.doi.org/10.1016/j.pmr.2023.04.004
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author Ramasamy, Akshara
Wang, Chumeng
Brode, W. Michael
Verduzco-Gutierrez, Monica
Melamed, Esther
author_facet Ramasamy, Akshara
Wang, Chumeng
Brode, W. Michael
Verduzco-Gutierrez, Monica
Melamed, Esther
author_sort Ramasamy, Akshara
collection PubMed
description The COVID-19 pandemic has resulted in a significant number of people developing long-term health effects of postacute sequelae SARS-CoV-2 infection (PASC). Both acute COVID-19 and PASC are now recognized as multiorgan diseases with multiple symptoms and disease causes. The development of immune dysregulation during acute COVID-19 and PASC is of high epidemiologic concern. Both conditions may also be influenced by comorbid conditions such as pulmonary dysfunction, cardiovascular disease, neuropsychiatric conditions, prior autoimmune conditions and cancer. This review discusses the clinical symptoms, pathophysiology, and risk factors that affect both acute COVID-19 and PASC.
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spelling pubmed-100861052023-04-11 Immunologic and Autoimmune-Related Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Clinical Symptoms and Mechanisms of Disease Ramasamy, Akshara Wang, Chumeng Brode, W. Michael Verduzco-Gutierrez, Monica Melamed, Esther Phys Med Rehabil Clin N Am Article The COVID-19 pandemic has resulted in a significant number of people developing long-term health effects of postacute sequelae SARS-CoV-2 infection (PASC). Both acute COVID-19 and PASC are now recognized as multiorgan diseases with multiple symptoms and disease causes. The development of immune dysregulation during acute COVID-19 and PASC is of high epidemiologic concern. Both conditions may also be influenced by comorbid conditions such as pulmonary dysfunction, cardiovascular disease, neuropsychiatric conditions, prior autoimmune conditions and cancer. This review discusses the clinical symptoms, pathophysiology, and risk factors that affect both acute COVID-19 and PASC. Elsevier Inc. 2023-04-11 /pmc/articles/PMC10086105/ /pubmed/37419536 http://dx.doi.org/10.1016/j.pmr.2023.04.004 Text en © 2023 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ramasamy, Akshara
Wang, Chumeng
Brode, W. Michael
Verduzco-Gutierrez, Monica
Melamed, Esther
Immunologic and Autoimmune-Related Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Clinical Symptoms and Mechanisms of Disease
title Immunologic and Autoimmune-Related Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Clinical Symptoms and Mechanisms of Disease
title_full Immunologic and Autoimmune-Related Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Clinical Symptoms and Mechanisms of Disease
title_fullStr Immunologic and Autoimmune-Related Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Clinical Symptoms and Mechanisms of Disease
title_full_unstemmed Immunologic and Autoimmune-Related Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Clinical Symptoms and Mechanisms of Disease
title_short Immunologic and Autoimmune-Related Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Clinical Symptoms and Mechanisms of Disease
title_sort immunologic and autoimmune-related sequelae of severe acute respiratory syndrome coronavirus 2 infection: clinical symptoms and mechanisms of disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086105/
https://www.ncbi.nlm.nih.gov/pubmed/37419536
http://dx.doi.org/10.1016/j.pmr.2023.04.004
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