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Case Report: Potential role of selective venous sampling for liquid biopsy in complex clinical settings: Three case presentations

Tumor mutation profiling from a blood sample, known as liquid biopsy, is a reality that has already been approved for some cancers. This molecular diagnostic method complements tissue biopsy but is less invasive and therefore more easily applied, especially during tumor evolution. Its use should all...

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Autores principales: Tichà, Vladimira, Patelli, Gianluigi, Basso, Gianpaolo, Prino, Aurelio, Repetti, Elena, Grugni, Maria, Damascelli, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086121/
https://www.ncbi.nlm.nih.gov/pubmed/37056288
http://dx.doi.org/10.3389/fgene.2023.1065537
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author Tichà, Vladimira
Patelli, Gianluigi
Basso, Gianpaolo
Prino, Aurelio
Repetti, Elena
Grugni, Maria
Damascelli, Bruno
author_facet Tichà, Vladimira
Patelli, Gianluigi
Basso, Gianpaolo
Prino, Aurelio
Repetti, Elena
Grugni, Maria
Damascelli, Bruno
author_sort Tichà, Vladimira
collection PubMed
description Tumor mutation profiling from a blood sample, known as liquid biopsy, is a reality that has already been approved for some cancers. This molecular diagnostic method complements tissue biopsy but is less invasive and therefore more easily applied, especially during tumor evolution. Its use should allow detection of residual disease, evaluation of treatment response or resistance, and selection of targeted treatments. However, implementation of liquid biopsy in routine clinical practice is hindered by unsolved issues, one of which is the scarcity of circulating tumor DNA in blood samples drawn from peripheral veins. To address this problem, we propose minimally invasive selective venous sampling from the region of interest, as used for some hormonal studies and for mapping of endocrine tumors. Intuitively, selective sampling should improve the sensitivity of liquid biopsy by avoiding the dilution of tumor biomarkers that occurs in the peripheral circulation. We report three cases that illustrate the potential utility of selective liquid biopsy in complex clinical settings, providing implications for diagnosis and treatment as well as for monitoring over time, disease localization, identification of drug resistance, and differential diagnosis.
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spelling pubmed-100861212023-04-12 Case Report: Potential role of selective venous sampling for liquid biopsy in complex clinical settings: Three case presentations Tichà, Vladimira Patelli, Gianluigi Basso, Gianpaolo Prino, Aurelio Repetti, Elena Grugni, Maria Damascelli, Bruno Front Genet Genetics Tumor mutation profiling from a blood sample, known as liquid biopsy, is a reality that has already been approved for some cancers. This molecular diagnostic method complements tissue biopsy but is less invasive and therefore more easily applied, especially during tumor evolution. Its use should allow detection of residual disease, evaluation of treatment response or resistance, and selection of targeted treatments. However, implementation of liquid biopsy in routine clinical practice is hindered by unsolved issues, one of which is the scarcity of circulating tumor DNA in blood samples drawn from peripheral veins. To address this problem, we propose minimally invasive selective venous sampling from the region of interest, as used for some hormonal studies and for mapping of endocrine tumors. Intuitively, selective sampling should improve the sensitivity of liquid biopsy by avoiding the dilution of tumor biomarkers that occurs in the peripheral circulation. We report three cases that illustrate the potential utility of selective liquid biopsy in complex clinical settings, providing implications for diagnosis and treatment as well as for monitoring over time, disease localization, identification of drug resistance, and differential diagnosis. Frontiers Media S.A. 2023-03-28 /pmc/articles/PMC10086121/ /pubmed/37056288 http://dx.doi.org/10.3389/fgene.2023.1065537 Text en Copyright © 2023 Tichà, Patelli, Basso, Prino, Repetti, Grugni and Damascelli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Tichà, Vladimira
Patelli, Gianluigi
Basso, Gianpaolo
Prino, Aurelio
Repetti, Elena
Grugni, Maria
Damascelli, Bruno
Case Report: Potential role of selective venous sampling for liquid biopsy in complex clinical settings: Three case presentations
title Case Report: Potential role of selective venous sampling for liquid biopsy in complex clinical settings: Three case presentations
title_full Case Report: Potential role of selective venous sampling for liquid biopsy in complex clinical settings: Three case presentations
title_fullStr Case Report: Potential role of selective venous sampling for liquid biopsy in complex clinical settings: Three case presentations
title_full_unstemmed Case Report: Potential role of selective venous sampling for liquid biopsy in complex clinical settings: Three case presentations
title_short Case Report: Potential role of selective venous sampling for liquid biopsy in complex clinical settings: Three case presentations
title_sort case report: potential role of selective venous sampling for liquid biopsy in complex clinical settings: three case presentations
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086121/
https://www.ncbi.nlm.nih.gov/pubmed/37056288
http://dx.doi.org/10.3389/fgene.2023.1065537
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