Cargando…
Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention
Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac fibrosis, which are modulated by multiple signalin...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086160/ https://www.ncbi.nlm.nih.gov/pubmed/37056987 http://dx.doi.org/10.3389/fphar.2023.1070973 |
_version_ | 1785022087762542592 |
---|---|
author | Yin, Xiaoying Yin, Xinxin Pan, Xin Zhang, Jingyu Fan, Xinhui Li, Jiaxin Zhai, Xiaoxuan Jiang, Lijun Hao, Panpan Wang, Jiali Chen, Yuguo |
author_facet | Yin, Xiaoying Yin, Xinxin Pan, Xin Zhang, Jingyu Fan, Xinhui Li, Jiaxin Zhai, Xiaoxuan Jiang, Lijun Hao, Panpan Wang, Jiali Chen, Yuguo |
author_sort | Yin, Xiaoying |
collection | PubMed |
description | Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac fibrosis, which are modulated by multiple signaling pathways and various types of cells in time-dependent manners. Our understanding of the development of cardiac fibrosis after MI has evolved in basic and clinical researches, and the regulation of fibrotic remodeling may facilitate novel diagnostic and therapeutic strategies, and finally improve outcomes. Here, we aim to elaborate pathophysiology, examination and intervention of cardiac fibrosis after MI. |
format | Online Article Text |
id | pubmed-10086160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100861602023-04-12 Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention Yin, Xiaoying Yin, Xinxin Pan, Xin Zhang, Jingyu Fan, Xinhui Li, Jiaxin Zhai, Xiaoxuan Jiang, Lijun Hao, Panpan Wang, Jiali Chen, Yuguo Front Pharmacol Pharmacology Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac fibrosis, which are modulated by multiple signaling pathways and various types of cells in time-dependent manners. Our understanding of the development of cardiac fibrosis after MI has evolved in basic and clinical researches, and the regulation of fibrotic remodeling may facilitate novel diagnostic and therapeutic strategies, and finally improve outcomes. Here, we aim to elaborate pathophysiology, examination and intervention of cardiac fibrosis after MI. Frontiers Media S.A. 2023-03-28 /pmc/articles/PMC10086160/ /pubmed/37056987 http://dx.doi.org/10.3389/fphar.2023.1070973 Text en Copyright © 2023 Yin, Yin, Pan, Zhang, Fan, Li, Zhai, Jiang, Hao, Wang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Yin, Xiaoying Yin, Xinxin Pan, Xin Zhang, Jingyu Fan, Xinhui Li, Jiaxin Zhai, Xiaoxuan Jiang, Lijun Hao, Panpan Wang, Jiali Chen, Yuguo Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention |
title | Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention |
title_full | Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention |
title_fullStr | Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention |
title_full_unstemmed | Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention |
title_short | Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention |
title_sort | post-myocardial infarction fibrosis: pathophysiology, examination, and intervention |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086160/ https://www.ncbi.nlm.nih.gov/pubmed/37056987 http://dx.doi.org/10.3389/fphar.2023.1070973 |
work_keys_str_mv | AT yinxiaoying postmyocardialinfarctionfibrosispathophysiologyexaminationandintervention AT yinxinxin postmyocardialinfarctionfibrosispathophysiologyexaminationandintervention AT panxin postmyocardialinfarctionfibrosispathophysiologyexaminationandintervention AT zhangjingyu postmyocardialinfarctionfibrosispathophysiologyexaminationandintervention AT fanxinhui postmyocardialinfarctionfibrosispathophysiologyexaminationandintervention AT lijiaxin postmyocardialinfarctionfibrosispathophysiologyexaminationandintervention AT zhaixiaoxuan postmyocardialinfarctionfibrosispathophysiologyexaminationandintervention AT jianglijun postmyocardialinfarctionfibrosispathophysiologyexaminationandintervention AT haopanpan postmyocardialinfarctionfibrosispathophysiologyexaminationandintervention AT wangjiali postmyocardialinfarctionfibrosispathophysiologyexaminationandintervention AT chenyuguo postmyocardialinfarctionfibrosispathophysiologyexaminationandintervention |