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Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac fibrosis, which are modulated by multiple signalin...

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Autores principales: Yin, Xiaoying, Yin, Xinxin, Pan, Xin, Zhang, Jingyu, Fan, Xinhui, Li, Jiaxin, Zhai, Xiaoxuan, Jiang, Lijun, Hao, Panpan, Wang, Jiali, Chen, Yuguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086160/
https://www.ncbi.nlm.nih.gov/pubmed/37056987
http://dx.doi.org/10.3389/fphar.2023.1070973
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author Yin, Xiaoying
Yin, Xinxin
Pan, Xin
Zhang, Jingyu
Fan, Xinhui
Li, Jiaxin
Zhai, Xiaoxuan
Jiang, Lijun
Hao, Panpan
Wang, Jiali
Chen, Yuguo
author_facet Yin, Xiaoying
Yin, Xinxin
Pan, Xin
Zhang, Jingyu
Fan, Xinhui
Li, Jiaxin
Zhai, Xiaoxuan
Jiang, Lijun
Hao, Panpan
Wang, Jiali
Chen, Yuguo
author_sort Yin, Xiaoying
collection PubMed
description Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac fibrosis, which are modulated by multiple signaling pathways and various types of cells in time-dependent manners. Our understanding of the development of cardiac fibrosis after MI has evolved in basic and clinical researches, and the regulation of fibrotic remodeling may facilitate novel diagnostic and therapeutic strategies, and finally improve outcomes. Here, we aim to elaborate pathophysiology, examination and intervention of cardiac fibrosis after MI.
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spelling pubmed-100861602023-04-12 Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention Yin, Xiaoying Yin, Xinxin Pan, Xin Zhang, Jingyu Fan, Xinhui Li, Jiaxin Zhai, Xiaoxuan Jiang, Lijun Hao, Panpan Wang, Jiali Chen, Yuguo Front Pharmacol Pharmacology Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac fibrosis, which are modulated by multiple signaling pathways and various types of cells in time-dependent manners. Our understanding of the development of cardiac fibrosis after MI has evolved in basic and clinical researches, and the regulation of fibrotic remodeling may facilitate novel diagnostic and therapeutic strategies, and finally improve outcomes. Here, we aim to elaborate pathophysiology, examination and intervention of cardiac fibrosis after MI. Frontiers Media S.A. 2023-03-28 /pmc/articles/PMC10086160/ /pubmed/37056987 http://dx.doi.org/10.3389/fphar.2023.1070973 Text en Copyright © 2023 Yin, Yin, Pan, Zhang, Fan, Li, Zhai, Jiang, Hao, Wang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Yin, Xiaoying
Yin, Xinxin
Pan, Xin
Zhang, Jingyu
Fan, Xinhui
Li, Jiaxin
Zhai, Xiaoxuan
Jiang, Lijun
Hao, Panpan
Wang, Jiali
Chen, Yuguo
Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention
title Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention
title_full Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention
title_fullStr Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention
title_full_unstemmed Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention
title_short Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention
title_sort post-myocardial infarction fibrosis: pathophysiology, examination, and intervention
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086160/
https://www.ncbi.nlm.nih.gov/pubmed/37056987
http://dx.doi.org/10.3389/fphar.2023.1070973
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