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Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications
Peroxynitrite (ONOO(-)), owing to its high oxidative and nitrating stress, is associated with several physiological processes in addition to various pathological processes, including those related to neurodegenerative diseases and cancer. Detection of ONOO(-) at the cellular level is of great signif...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086199/ https://www.ncbi.nlm.nih.gov/pubmed/37056560 http://dx.doi.org/10.7150/thno.80529 |
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author | Sun, Jiarao Cao, Xiaoli Lu, Wenjuan Wei, Yongchun Kong, Lingxiu Chen, Wei Shao, Xintian Wang, Yanfeng |
author_facet | Sun, Jiarao Cao, Xiaoli Lu, Wenjuan Wei, Yongchun Kong, Lingxiu Chen, Wei Shao, Xintian Wang, Yanfeng |
author_sort | Sun, Jiarao |
collection | PubMed |
description | Peroxynitrite (ONOO(-)), owing to its high oxidative and nitrating stress, is associated with several physiological processes in addition to various pathological processes, including those related to neurodegenerative diseases and cancer. Detection of ONOO(-) at the cellular level is of great significance to understand its pathogenesis. To this end, a variety of fluorescent probes based on small molecules and nanoparticles (NPs) have been engineered and applied as excellent tools for imaging of ONOO(-) in cells as well as in their diverse biological applications. In this review, we highlight representative cases of fluorescent probes based on recognition mechanism and emphasize their response type (ratiometric, two-photon, long-wavelength/near-infrared, and targeting) in ONOO(-) detection in the last five years. We further discuss their design strategy, sensing mechanism, and application in bio-imaging and describe NP-based probes according to diverse nanoplatforms. |
format | Online Article Text |
id | pubmed-10086199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-100861992023-04-12 Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications Sun, Jiarao Cao, Xiaoli Lu, Wenjuan Wei, Yongchun Kong, Lingxiu Chen, Wei Shao, Xintian Wang, Yanfeng Theranostics Review Peroxynitrite (ONOO(-)), owing to its high oxidative and nitrating stress, is associated with several physiological processes in addition to various pathological processes, including those related to neurodegenerative diseases and cancer. Detection of ONOO(-) at the cellular level is of great significance to understand its pathogenesis. To this end, a variety of fluorescent probes based on small molecules and nanoparticles (NPs) have been engineered and applied as excellent tools for imaging of ONOO(-) in cells as well as in their diverse biological applications. In this review, we highlight representative cases of fluorescent probes based on recognition mechanism and emphasize their response type (ratiometric, two-photon, long-wavelength/near-infrared, and targeting) in ONOO(-) detection in the last five years. We further discuss their design strategy, sensing mechanism, and application in bio-imaging and describe NP-based probes according to diverse nanoplatforms. Ivyspring International Publisher 2023-03-13 /pmc/articles/PMC10086199/ /pubmed/37056560 http://dx.doi.org/10.7150/thno.80529 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Sun, Jiarao Cao, Xiaoli Lu, Wenjuan Wei, Yongchun Kong, Lingxiu Chen, Wei Shao, Xintian Wang, Yanfeng Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications |
title | Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications |
title_full | Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications |
title_fullStr | Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications |
title_full_unstemmed | Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications |
title_short | Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications |
title_sort | recent advances in fluorescent probes of peroxynitrite: structural, strategies and biological applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086199/ https://www.ncbi.nlm.nih.gov/pubmed/37056560 http://dx.doi.org/10.7150/thno.80529 |
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