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Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications

Peroxynitrite (ONOO(-)), owing to its high oxidative and nitrating stress, is associated with several physiological processes in addition to various pathological processes, including those related to neurodegenerative diseases and cancer. Detection of ONOO(-) at the cellular level is of great signif...

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Autores principales: Sun, Jiarao, Cao, Xiaoli, Lu, Wenjuan, Wei, Yongchun, Kong, Lingxiu, Chen, Wei, Shao, Xintian, Wang, Yanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086199/
https://www.ncbi.nlm.nih.gov/pubmed/37056560
http://dx.doi.org/10.7150/thno.80529
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author Sun, Jiarao
Cao, Xiaoli
Lu, Wenjuan
Wei, Yongchun
Kong, Lingxiu
Chen, Wei
Shao, Xintian
Wang, Yanfeng
author_facet Sun, Jiarao
Cao, Xiaoli
Lu, Wenjuan
Wei, Yongchun
Kong, Lingxiu
Chen, Wei
Shao, Xintian
Wang, Yanfeng
author_sort Sun, Jiarao
collection PubMed
description Peroxynitrite (ONOO(-)), owing to its high oxidative and nitrating stress, is associated with several physiological processes in addition to various pathological processes, including those related to neurodegenerative diseases and cancer. Detection of ONOO(-) at the cellular level is of great significance to understand its pathogenesis. To this end, a variety of fluorescent probes based on small molecules and nanoparticles (NPs) have been engineered and applied as excellent tools for imaging of ONOO(-) in cells as well as in their diverse biological applications. In this review, we highlight representative cases of fluorescent probes based on recognition mechanism and emphasize their response type (ratiometric, two-photon, long-wavelength/near-infrared, and targeting) in ONOO(-) detection in the last five years. We further discuss their design strategy, sensing mechanism, and application in bio-imaging and describe NP-based probes according to diverse nanoplatforms.
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spelling pubmed-100861992023-04-12 Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications Sun, Jiarao Cao, Xiaoli Lu, Wenjuan Wei, Yongchun Kong, Lingxiu Chen, Wei Shao, Xintian Wang, Yanfeng Theranostics Review Peroxynitrite (ONOO(-)), owing to its high oxidative and nitrating stress, is associated with several physiological processes in addition to various pathological processes, including those related to neurodegenerative diseases and cancer. Detection of ONOO(-) at the cellular level is of great significance to understand its pathogenesis. To this end, a variety of fluorescent probes based on small molecules and nanoparticles (NPs) have been engineered and applied as excellent tools for imaging of ONOO(-) in cells as well as in their diverse biological applications. In this review, we highlight representative cases of fluorescent probes based on recognition mechanism and emphasize their response type (ratiometric, two-photon, long-wavelength/near-infrared, and targeting) in ONOO(-) detection in the last five years. We further discuss their design strategy, sensing mechanism, and application in bio-imaging and describe NP-based probes according to diverse nanoplatforms. Ivyspring International Publisher 2023-03-13 /pmc/articles/PMC10086199/ /pubmed/37056560 http://dx.doi.org/10.7150/thno.80529 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Sun, Jiarao
Cao, Xiaoli
Lu, Wenjuan
Wei, Yongchun
Kong, Lingxiu
Chen, Wei
Shao, Xintian
Wang, Yanfeng
Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications
title Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications
title_full Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications
title_fullStr Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications
title_full_unstemmed Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications
title_short Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications
title_sort recent advances in fluorescent probes of peroxynitrite: structural, strategies and biological applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086199/
https://www.ncbi.nlm.nih.gov/pubmed/37056560
http://dx.doi.org/10.7150/thno.80529
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