Cargando…
Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis
Liver fibrosis is a repair response to injury caused by various chronic stimuli that continually act on the liver. Among them, the activation of hepatic stellate cells (HSCs) and their transformation into a myofibroblast phenotype is a key event leading to liver fibrosis, however the mechanism has n...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086238/ https://www.ncbi.nlm.nih.gov/pubmed/37056286 http://dx.doi.org/10.3389/fgene.2023.1124330 |
_version_ | 1785022106514227200 |
---|---|
author | Lyu, Shi-Yi Xiao, Wang Cui, Guang-Zu Yu, Cheng Liu, Huan Lyu, Min Kuang, Qian-Ya Xiao, En-Hua Luo, Yong-Heng |
author_facet | Lyu, Shi-Yi Xiao, Wang Cui, Guang-Zu Yu, Cheng Liu, Huan Lyu, Min Kuang, Qian-Ya Xiao, En-Hua Luo, Yong-Heng |
author_sort | Lyu, Shi-Yi |
collection | PubMed |
description | Liver fibrosis is a repair response to injury caused by various chronic stimuli that continually act on the liver. Among them, the activation of hepatic stellate cells (HSCs) and their transformation into a myofibroblast phenotype is a key event leading to liver fibrosis, however the mechanism has not yet been elucidated. The molecular basis of HSC activation involves changes in the regulation of gene expression without changes in the genome sequence, namely, via epigenetic regulation. DNA methylation is a key focus of epigenetic research, as it affects the expression of fibrosis-related, metabolism-related, and tumor suppressor genes. Increasing studies have shown that DNA methylation is closely related to several physiological and pathological processes including HSC activation and liver fibrosis. This review aimed to discuss the mechanism of DNA methylation in the pathogenesis of liver fibrosis, explore DNA methylation inhibitors as potential therapies for liver fibrosis, and provide new insights on the prevention and clinical treatment of liver fibrosis. |
format | Online Article Text |
id | pubmed-10086238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100862382023-04-12 Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis Lyu, Shi-Yi Xiao, Wang Cui, Guang-Zu Yu, Cheng Liu, Huan Lyu, Min Kuang, Qian-Ya Xiao, En-Hua Luo, Yong-Heng Front Genet Genetics Liver fibrosis is a repair response to injury caused by various chronic stimuli that continually act on the liver. Among them, the activation of hepatic stellate cells (HSCs) and their transformation into a myofibroblast phenotype is a key event leading to liver fibrosis, however the mechanism has not yet been elucidated. The molecular basis of HSC activation involves changes in the regulation of gene expression without changes in the genome sequence, namely, via epigenetic regulation. DNA methylation is a key focus of epigenetic research, as it affects the expression of fibrosis-related, metabolism-related, and tumor suppressor genes. Increasing studies have shown that DNA methylation is closely related to several physiological and pathological processes including HSC activation and liver fibrosis. This review aimed to discuss the mechanism of DNA methylation in the pathogenesis of liver fibrosis, explore DNA methylation inhibitors as potential therapies for liver fibrosis, and provide new insights on the prevention and clinical treatment of liver fibrosis. Frontiers Media S.A. 2023-03-28 /pmc/articles/PMC10086238/ /pubmed/37056286 http://dx.doi.org/10.3389/fgene.2023.1124330 Text en Copyright © 2023 Lyu, Xiao, Cui, Yu, Liu, Lyu, Kuang, Xiao and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Lyu, Shi-Yi Xiao, Wang Cui, Guang-Zu Yu, Cheng Liu, Huan Lyu, Min Kuang, Qian-Ya Xiao, En-Hua Luo, Yong-Heng Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis |
title | Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis |
title_full | Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis |
title_fullStr | Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis |
title_full_unstemmed | Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis |
title_short | Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis |
title_sort | role and mechanism of dna methylation and its inhibitors in hepatic fibrosis |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086238/ https://www.ncbi.nlm.nih.gov/pubmed/37056286 http://dx.doi.org/10.3389/fgene.2023.1124330 |
work_keys_str_mv | AT lyushiyi roleandmechanismofdnamethylationanditsinhibitorsinhepaticfibrosis AT xiaowang roleandmechanismofdnamethylationanditsinhibitorsinhepaticfibrosis AT cuiguangzu roleandmechanismofdnamethylationanditsinhibitorsinhepaticfibrosis AT yucheng roleandmechanismofdnamethylationanditsinhibitorsinhepaticfibrosis AT liuhuan roleandmechanismofdnamethylationanditsinhibitorsinhepaticfibrosis AT lyumin roleandmechanismofdnamethylationanditsinhibitorsinhepaticfibrosis AT kuangqianya roleandmechanismofdnamethylationanditsinhibitorsinhepaticfibrosis AT xiaoenhua roleandmechanismofdnamethylationanditsinhibitorsinhepaticfibrosis AT luoyongheng roleandmechanismofdnamethylationanditsinhibitorsinhepaticfibrosis |