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Microbial transmission, colonisation and succession: from pregnancy to infancy

The microbiome has been proven to be associated with many diseases and has been used as a biomarker and target in disease prevention and intervention. Currently, the vital role of the microbiome in pregnant women and newborns is increasingly emphasised. In this review, we discuss the interplay of th...

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Autores principales: Xiao, Liwen, Zhao, Fangqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086306/
https://www.ncbi.nlm.nih.gov/pubmed/36720630
http://dx.doi.org/10.1136/gutjnl-2022-328970
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author Xiao, Liwen
Zhao, Fangqing
author_facet Xiao, Liwen
Zhao, Fangqing
author_sort Xiao, Liwen
collection PubMed
description The microbiome has been proven to be associated with many diseases and has been used as a biomarker and target in disease prevention and intervention. Currently, the vital role of the microbiome in pregnant women and newborns is increasingly emphasised. In this review, we discuss the interplay of the microbiome and the corresponding immune mechanism between mothers and their offspring during the perinatal period. We aim to present a comprehensive picture of microbial transmission and potential immune imprinting before and after delivery. In addition, we discuss the possibility of in utero microbial colonisation during pregnancy, which has been highly debated in recent studies, and highlight the importance of the microbiome in infant development during the first 3 years of life. This holistic view of the role of the microbial interplay between mothers and infants will refine our current understanding of pregnancy complications as well as diseases in early life and will greatly facilitate the microbiome-based prenatal diagnosis and treatment of mother-infant-related diseases.
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spelling pubmed-100863062023-04-12 Microbial transmission, colonisation and succession: from pregnancy to infancy Xiao, Liwen Zhao, Fangqing Gut Recent Advances in Basic Science The microbiome has been proven to be associated with many diseases and has been used as a biomarker and target in disease prevention and intervention. Currently, the vital role of the microbiome in pregnant women and newborns is increasingly emphasised. In this review, we discuss the interplay of the microbiome and the corresponding immune mechanism between mothers and their offspring during the perinatal period. We aim to present a comprehensive picture of microbial transmission and potential immune imprinting before and after delivery. In addition, we discuss the possibility of in utero microbial colonisation during pregnancy, which has been highly debated in recent studies, and highlight the importance of the microbiome in infant development during the first 3 years of life. This holistic view of the role of the microbial interplay between mothers and infants will refine our current understanding of pregnancy complications as well as diseases in early life and will greatly facilitate the microbiome-based prenatal diagnosis and treatment of mother-infant-related diseases. BMJ Publishing Group 2023-04 2023-01-31 /pmc/articles/PMC10086306/ /pubmed/36720630 http://dx.doi.org/10.1136/gutjnl-2022-328970 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Recent Advances in Basic Science
Xiao, Liwen
Zhao, Fangqing
Microbial transmission, colonisation and succession: from pregnancy to infancy
title Microbial transmission, colonisation and succession: from pregnancy to infancy
title_full Microbial transmission, colonisation and succession: from pregnancy to infancy
title_fullStr Microbial transmission, colonisation and succession: from pregnancy to infancy
title_full_unstemmed Microbial transmission, colonisation and succession: from pregnancy to infancy
title_short Microbial transmission, colonisation and succession: from pregnancy to infancy
title_sort microbial transmission, colonisation and succession: from pregnancy to infancy
topic Recent Advances in Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086306/
https://www.ncbi.nlm.nih.gov/pubmed/36720630
http://dx.doi.org/10.1136/gutjnl-2022-328970
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